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Case Reports
. 2018 Jun 27:2018:bcr2018225294.
doi: 10.1136/bcr-2018-225294.

Stage 1 small cell cancer of the vagina

Tarek Haykal  1 , Trailokya Pandit  1 , Ghassan Bachuwa  1 , Rizwan Danish  1
Affiliations
Case Reports

Stage 1 small cell cancer of the vagina

Tarek Haykal et al. BMJ Case Rep. .

Abstract

This is the case of a 56-year-old white woman with a medical history significant for chronic obstructive pulmonary disease, migraine, hypertension, tobacco abuse and hypercholesterolaemia. Her surgical history is significant for total hysterectomy and bilateral salpingo-oophorectomy for diffuse endometriosis. The patient presented with a vaginal lesion. The biopsy was positive for primary vaginal small cell carcinoma and human papilloma virus (HPV). Initial staging positron emission tomography (PET) scan confirmed stage 1 disease. The patient was started on chemotherapy with cisplatin and etoposide for four cycles, followed by concurrent chemotherapy with cisplatin/taxol and radiation therapy.

Keywords: malignant disease and immunosuppression; obstetrics, gynaecology and fertility; urinary and genital tract disorders.

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Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
Low power view of neuroendocrine carcinoma showing diffuse uniform population of cells (H&E, x10).
Figure 2
Figure 2
High power view of neuroendocrine carcinoma. The cells have uniform round nuclei with granular chromatin, micronucleoli and scant cytoplasm. Numerous mitotic figures are seen (H&E, x40).
Figure 3
Figure 3
The tumour cells show positive cytoplasmic staining for synaptophysin (x40).
Figure 4
Figure 4
Neuroendocrine tumour cells on Pap smear (x40).
See this image and copyright information in PMC

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