Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2018 Jun 27:2018:bcr2018224338.
doi: 10.1136/bcr-2018-224338.

Possible SAMe-induced mania

Hesitha Abeysundera  1 , Ramandeep Gill  2
Affiliations
Case Reports

Possible SAMe-induced mania

Hesitha Abeysundera et al. BMJ Case Rep. .

Abstract

This paper describes a patient who presented with mania with psychotic features in the context of concomitant use of S-adenosyl-L-methionine (SAMe) and selective serotonin reuptake inhibitor (SSRI). The aim of this case report is to provide medical practitioners with a greater awareness of the possibility of a psychotic episode and/or mania manifesting with concurrent use of SAMe and SSRI.

Keywords: bipolar I disorder; depressive disorder; drugs: psychiatry; psychiatry (drugs and medicines); psychotic disorders (incl schizophrenia).

PubMed Disclaimer

Conflict of interest statement

Competing interests: None declared.

References

    1. CATONI GL. S-Adenosylmethionine; a new intermediate formed enzymatically from L-methionine and adenosinetriphosphate. J Biol Chem 1953;204:403–16. - PubMed
    1. Galizia I, Oldani L, Macritchie K, et al. . S-adenosyl methionine (SAMe) for depression in adults. Cochrane Database Syst Rev 2016;10:CD011286 10.1002/14651858.CD011286.pub2 - DOI - PMC - PubMed
    1. Jacobsen S, Danneskiold-Samsoe B, Andersen RB. Oral S-adenosymethionine in primary fibromyalgia. Scand J Rheumatol 1991;20:294–302. - PubMed
    1. Brown RP, Gerbarg PL, Bottiglieri T. S-adenosylmethionine in clinical practice of psychiatry, neurology and internal medicine. Clinical Practice of Alternative Medicine 2000;1:230–41.
    1. Friedel HA, Goa KL, Benfield P. S-adenosyl-L-methionine. A review of its pharmacological properties and therapeutic potential in liver dysfunction and affective disorders in relation to its physiological role in cell metabolism. Drugs 1989;38:389–416. - PubMed

Publication types

MeSH terms