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. 1985 Sep 10;115(1):97-101.
doi: 10.1016/0014-2999(85)90589-8.

Localization of beta-adrenoceptors in the rabbit ear by light microscopic autoradiography

H G Johnston, R J Summers

Localization of beta-adrenoceptors in the rabbit ear by light microscopic autoradiography

H G Johnston et al. Eur J Pharmacol. .

Abstract

The beta-adrenoceptor antagonist [125I]cyanopindolol (CYP) was used to localize beta-adrenoceptors in sections of rabbit ear. Biochemical studies demonstrated that the binding was stereoselective, and that the beta-adrenoceptors are predominantly of the beta 2-subtype. Autoradiographic studies using 3H-Ultrofilm or nuclear emulsion coated coverslips showed high concentrations of beta 2-adrenoceptors present in the central ear artery, hyaline cartilage, nerve trunks, epithelium and sebaceous glands.

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