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Review
. 2018 Jun 22:10:19-28.
doi: 10.2147/JEP.S162059. eCollection 2018.

Cannabinoids and agmatine as potential therapeutic alternatives for cisplatin-induced peripheral neuropathy

Basak Donertas #  1 , Cigdem Cengelli Unel #  1 , Kevser Erol  1
Affiliations
Review

Cannabinoids and agmatine as potential therapeutic alternatives for cisplatin-induced peripheral neuropathy

Basak Donertas et al. J Exp Pharmacol. .

Abstract

Cisplatin is a widely used antineoplastic agent in the treatment of various cancers. Peripheral neuropathy is a well-known side effect of cisplatin and has the potential to result in limiting and/or reducing the dose, decreasing the quality of life. Unfortunately, the mechanism for cisplatin-induced neuropathy has not been completely elucidated. Currently, available treatments for neuropathic pain (NP) are mostly symptomatic, insufficient and are often linked with several detrimental side effects; thus, effective treatments are needed. Cannabinoids and agmatine are endogenous modulators that are implicated in painful states. This review explains the cisplatin-induced neuropathy and antinociceptive effects of cannabinoids and agmatine in animal models of NP and their putative therapeutic potential in cisplatin-induced neuropathy.

Keywords: agmatine; anandamide; cisplatin; neuropathy.

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Conflict of interest statement

Disclosure The authors report no conflicts of interest in this work.

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