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Review
. 2018 Mar;13(1):22-26.
doi: 10.1159/000486330. Epub 2018 Jan 31.

Immunooncology in Breast Cancer: Active and Passive Vaccination Strategies

Florian Schütz  1 , Frederik Marmé  2 , Christoph Domschke  1 , Christof Sohn  3 , Alexandra von Au  1
Affiliations
Review

Immunooncology in Breast Cancer: Active and Passive Vaccination Strategies

Florian Schütz et al. Breast Care (Basel). 2018 Mar.

Abstract

Immunotherapies are set to become part of the therapeutic repertoire for breast cancer in the near future. Active vaccination is a promising strategy, especially in tumors that have a specific tumor-associated antigen. Although cellular immunotherapies have not yet shown efficacy, new technologies are on the way to improve this approach. Given the recent Food and Drug Administration approval of chimeric antigen receptor (CAR) T cells for leukemia, it is only a question of time before solid tumors will follow. However, not all breast cancer patients will respond to cellular or other immunotherapy. Hence, we must define subpopulations of breast cancer patients who benefit from this new approach.

Keywords: Dendritic cells; Immunotherapy; T cells; Vaccines.

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