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Case Reports
. 2018 Jun 20:5:e48.
doi: 10.14309/crj.2018.48. eCollection 2018.

Infliximab-Induced Aseptic Meningitis in a Patient with Crohn's Disease

Zachary Junga  1 , Brett Theeler  2 , Manish Singla  1
Affiliations
Case Reports

Infliximab-Induced Aseptic Meningitis in a Patient with Crohn's Disease

Zachary Junga et al. ACG Case Rep J. .

Abstract

Infliximab is an anti-tumor necrosis factor α (TNFα) monoclonal antibody that treats moderate-to-severe Crohn's disease. In rare cases, infliximab has been associated with drug-induced aseptic meningitis. We present a 46-year-old woman with migraines and inflammatory Crohn's colitis treated with intravenous infliximab and methotrexate. She developed nuchal rigidity, photophobia, and headache 2 days after each of her infliximab infusions, with symptom resolution 1 week post-infusion. Her exam, imaging, and cerebrospinal fluid analysis were consistent with drug-induced aseptic meningitis. She discontinued infliximab and started vedolizumab with continued remission of her Crohn's disease.

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