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. 2018 Aug 21;54(65):8987-8990.
doi: 10.1039/c8cc02131g. Epub 2018 Jun 28.

A ruthenium-platinum metal complex that binds to sarcin ricin loop RNA and lowers mRNA expression

Swapan S Jain  1 , Craig M Anderson  1 , Iden A Sapse  1 , Silvie H Lundgren  1 , Abigail K Freer  1 , Hang Hoang  1 , Kyan Jain  1 , Madeleine Breshears  1
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A ruthenium-platinum metal complex that binds to sarcin ricin loop RNA and lowers mRNA expression

Swapan S Jain et al. Chem Commun (Camb). .

Abstract

IT127 is a dinuclear transition metal complex that contains a Pt(ii) and a Ru(iii) metal center. We have shown that IT127 is significantly more effective in binding the 29-base sarcin ricin loop (SRL) RNA in comparison to Cisplatin, a hallmark anticancer agent. Binding site analysis shows that IT127 prefers purine bases and the GAGA tetraloop region of SRL RNA. Our results with a dihydrofolate reductase (DHFR) model system reveal that IT127 binding to mRNA reduces translation of DHFR enzyme and that the Ru(iii) and Pt(ii) centers in IT127 appear to work in a synergistic manner.

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