Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Jan-Dec:17:1536012118782322.
doi: 10.1177/1536012118782322.

An Exploratory Study of Washout Rate Analysis for Thallium-201 Single-Photon Emission Computed Tomography Myocardial Perfusion Imaging Using Cadmium Zinc Telluride Detectors

Masaru Ishihara  1   2 , Masahisa Onoguchi  2 , Takayuki Shibutani  2
Affiliations

An Exploratory Study of Washout Rate Analysis for Thallium-201 Single-Photon Emission Computed Tomography Myocardial Perfusion Imaging Using Cadmium Zinc Telluride Detectors

Masaru Ishihara et al. Mol Imaging. 2018 Jan-Dec.

Abstract

The aim of this study was to assess the washout rate (WOR) for thallium-201-chloride single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) using cadmium zinc telluride detectors for SPECT (CZT SPECT) versus conventional Anger-type SPECT (conventional SPECT). A total of 52 Japanese patients were examined using CZT SPECT and conventional SPECT, and the global WORs were compared. Additionally, the MPI WORs were compared for patients with a normal MPI versus those in whom MPI reflected the patients' multivessel disease (MVD) MPI. Washout rates were similar when approximated by CZT SPECT versus conventional SPECT 12.59 ± 2.26%/h vs 12.57 ± 2.27%/h ( P = .997), respectively. The WOR values for CZT SPECT versus conventional SPECT were 13.42%/h (1.53%/h) vs 13.93%/h (1.24%/h) ( P = .337), respectively, for 7 normal MPI patients, and 10.64 ± 2.20%/h vs 10.84 ± 2.26%/h ( P = .848), respectively, for 7 MVD-MPI patients. The WOR values for normal MPI versus MVD-MPI patients for CZT SPECT were 13.42 ± 1.53%/h vs 10.64 ± 2.20%/h ( P = .025), respectively. Thallium-201-chloride WOR values obtained with high-efficiency CZT SPECT, which enabled significantly reduced imaging times and use of a low-dose protocol, were similar to those obtained with conventional SPECT.

Keywords: cadmium zinc telluride detectors; myocardial perfusion imaging; single-photon emission computed tomography; thallium-201-chloride; washout rate.

PubMed Disclaimer

Conflict of interest statement

Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Study protocol for stress/redistribution myocardial perfusion imaging with thallium-201-chloride (201Tl).
Figure 2.
Figure 2.
Linear regression analysis (A) and Bland-Altman plots (B) for cadmium zinc telluride single-photon emission computed tomography (CZT SPECT) and conventional SPECT.
Figure 3.
Figure 3.
An 80-year-old woman was found to have an abdominal aortic aneurysm during a preoperative cardiac evaluation. A, Contrast-enhanced computed tomography shows an infrarenal abdominal aortic aneurysm. B, Cadmium zinc telluride (CZT) single-photon emission computed tomography (SPECT) stress images (top row), redistribution images (bottom row), and washout rate (WOR) (at 15.6%/h) image. C, Conventional SPECT stress images (top row), redistribution images (bottom row), and WOR (at 14.8%/h) image.
Figure 4.
Figure 4.
A 76-year-old man with effort angina pectoris. A, Invasive coronary angiography shows 3-vessel disease. B, Cadmium zinc telluride (CZT) single-photon emission computed tomography (SPECT) stress images (top row), redistribution images (bottom row), and washout rate (WOR) (at 8.7%/h) image. C, Conventional SPECT stress images (top row), redistribution images (bottom row), and WOR (at 8.6%/h) image.
See this image and copyright information in PMC

References

    1. Chen CC, Huang WS, Hung GU, et al. Left-ventricular dyssynchrony evaluated by thallium-201 gated SPECT myocardial perfusion imaging: a comparison with Tc-99 m sestamibi. Nucl Med Commun. 2013;34(3):229–232. - PMC - PubMed
    1. Shiraishi S, Sakamoto F, Tsuda N, et al. Prediction of left main or 3-vessel disease using myocardial perfusion reserve on dynamic thallium-201 single-photon emission computed tomography with a semiconductor gamma camera. Circ J. 2015;79(3):623–631. - PubMed
    1. Ishihara M, Taniguchi Y, Onoguchi M, et al. Optimal thallium-201 dose in cadmium-zinc-telluride SPECT myocardial perfusion imaging. J Nucl Cardiol. 2018;25(3):947–954. - PubMed
    1. Bateman TM, Maddahi J, Gray RJ, et al. Diffuse slow washout of myocardial thallium-201: a new scintigraphic indicator of extensive coronary artery disease. J Am Coll Cardiol. 1984;4(1):55–64. - PubMed
    1. Koskinen M, Pöyhönen L, Seppänen S. Thallium-201 washout in coronary artery disease using SPECT—a comparison with coronary angiography. Eur J Nucl Med. 1987;12(12):609–612. - PubMed

LinkOut - more resources