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. 2018 Jul 17;57(28):4045-4046.
doi: 10.1021/acs.biochem.8b00622. Epub 2018 Jun 28.

How Do Intrinsically Disordered Viral Proteins Hijack the Cell?

H Jane Dyson  1 , Peter E Wright  1
Affiliations

How Do Intrinsically Disordered Viral Proteins Hijack the Cell?

H Jane Dyson et al. Biochemistry. .
No abstract available

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Figures

Figure 1.
Figure 1.
Schematic diagram of the cell cycle and its control mechanism. A. General cell cycle showing phases where growth, DNA replication and cell division occur. B. Role of pRb in the cell cycle. pRb dephosphorylated during the mitotic phase binds transcription factors E2F and DP, preventing the cell from proceeding through the G1 checkpoint. C. The normal signal to proceed through the G1 checkpoint is given by the degradation of p21 in the Cdk2-cyclin E complex, releasing Cdk2, which phosphorylates pRb, leading to the release of E2F and DP. D. HPV subverts the normal cell cycle by releasing the G1 checkpoint without the normal signal from the Cdk2-cyclin E complex.
Figure 2.
Figure 2.
Model for pRb:CBP:E7 ternary complex formation. E7 dimerization through the CR3 domain facilitates recruitment of CBP to Rb. The disordered CR1/CR2 domain of one monomer interacts with the pRb B domain, while the other interact with TAZ2 in a ternary complex that brings the catalytic HAT domain of CBP close to the pRb C domain, enabling acetylation at pRb lysines 873 and 874 and promoting pRb degradation. (Reproduced with permission from ref. 4).
See this image and copyright information in PMC

References

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    1. Oh KJ, Kalinina A, and Bagchi S (2010) Destabilization of Rb by human papillomavirus E7 is cell cycle dependent: E2-25K is involved in the proteolysis, Virology 396, 118–124. - PMC - PubMed

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