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Review
. 2019 Nov:131:104209.
doi: 10.1016/j.nbd.2018.06.021. Epub 2018 Jun 25.

Neuroimaging markers of antipsychotic treatment response in schizophrenia: An overview of magnetic resonance imaging studies

Goda Tarcijonas  1 , Deepak K Sarpal  2
Affiliations
Review

Neuroimaging markers of antipsychotic treatment response in schizophrenia: An overview of magnetic resonance imaging studies

Goda Tarcijonas et al. Neurobiol Dis. 2019 Nov.

Abstract

Antipsychotic drugs are the primary treatment for psychosis, yet individual response to their administration remains variable. At present, no biological predictors of response exist to guide clinicians as they select treatments for patients, and our understanding of the neurobiology underlying the heterogeneity of outcomes remains limited. Magnetic Resonance Imaging (MRI) has been applied by numerous studies to examine the response to antipsychotic treatment, though a large gap remains between their results and our clinical practice. To advance patient care with precision medicine approaches, prior work must be accounted for and built upon with future studies. This review provides an overview of studies that relate treatment outcome to various MRI-related measures, including structural, spectroscopic, diffusion tensor, and functional imaging. Knowledge derived from these studies will be discussed along with future directions for the field.

Keywords: Antipsychotic; Functional connectivity; MRI; Psychosis; Schizophrenia; Structural MRI; Treatment outcomes; Treatment response; fMRI.

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