Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1985 Oct;101(4):1623-6.
doi: 10.1083/jcb.101.4.1623.

A unique family of endothelial cell polypeptide mitogens: the antigenic and receptor cross-reactivity of bovine endothelial cell growth factor, brain-derived acidic fibroblast growth factor, and eye-derived growth factor-II

A B Schreiber, J Kenney, J Kowalski, K A Thomas, G Gimenez-Gallego, M Rios-Candelore, J Di Salvo, D Barritault, J Courty, Y Courtois, M Moenner, C Loret, W H Burgess, T Mehlman, R Friesel, W Johnson, T Maciag

A unique family of endothelial cell polypeptide mitogens: the antigenic and receptor cross-reactivity of bovine endothelial cell growth factor, brain-derived acidic fibroblast growth factor, and eye-derived growth factor-II

A B Schreiber et al. J Cell Biol. 1985 Oct.

Abstract

Bovine brain, hypothalamus, pituitary, and retina contain potent anionic polypeptide mitogens for endothelial cells. Immunological assays using murine monoclonal antibodies against bovine endothelial cell growth factor (ECGF) and radioreceptor assays using [125I]ECGF were performed to determine the cross-reactivity of ECGF with bovine acidic pI brain-derived fibroblast growth factor (acidic FGF) and bovine eye-derived growth factor-II [EDGF-II). We observed that acidic FGF and EDGF-II are recognized by anti-ECGF monoclonal antibodies and compete with [125I] ECGF for receptor occupancy. Furthermore, the biological activity of ECGF, acidic FGF, and EDGF-II is potentiated by the glycosaminoglycan, heparin. These results argue that ECGF, acidic FGF, and EDGF-II belong to a common family of polypeptide growth factors.

PubMed Disclaimer

References

    1. Ann Intern Med. 1975 Jan;82(1):96-100 - PubMed
    1. Biochem Biophys Res Commun. 1984 Oct 15;124(1):262-8 - PubMed
    1. J Biol Chem. 1981 Jan 10;256(1):54-8 - PubMed
    1. Differentiation. 1981;18(1):29-42 - PubMed
    1. J Biol Chem. 1982 Aug 25;257(16):9692-7 - PubMed

Publication types

MeSH terms