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. 2018 Jun 4;4(1):e000671.
doi: 10.1136/rmdopen-2018-000671. eCollection 2018.

Trends in hip fracture in patients with rheumatoid arthritis: results from the Spanish National Inpatient Registry over a 17-year period (1999-2015). TREND-AR study

Ramón Mazzucchelli  1 , Elia Pérez Fernandez  2 , Natalia Crespí-Villarías  3 , Javier Quirós-Donate  1 , Alberto García Vadillo  4 , María Espinosa  5 , Marina Peña  6 , Cristina Macía-Villa  7 , Jose Luis Morell-Hita  8 , Cristina Martinez-Prada  9 , Virginia Villaverde  10 , Inmaculada Morado Quiroga  9 , Olalla Guzón-Illescas  6 , Carmen Barbadillo  5 , Manuel Fernández Prada  11 , Hilda Godoy  5 , Angela Herranz Varela  12 , María Galindo Izquierdo  13 , Gil Rodriguez Caravaca  14
Affiliations

Trends in hip fracture in patients with rheumatoid arthritis: results from the Spanish National Inpatient Registry over a 17-year period (1999-2015). TREND-AR study

Ramón Mazzucchelli et al. RMD Open. .

Abstract

Purpose: To analyse trends in hip fracture (HF) rates in patients with rheumatoid arthritis (RA) over an extended time period (17 years).

Methods: This observational retrospective survey was performed by reviewing data from the National Surveillance System for Hospital Data, which includes more than 98% of Spanish hospitals. All hospitalisations of patients with RA and HF that were reported from 1999 to 2015 were analysed. Codes were selected using the Ninth International Classification of Diseases, Clinical Modification: ICD-9-CM: RA 714.0 to 714.9 and HF 820.0 to 820.3. The crude and age-adjusted incidence rate of HF was calculated by age and sex strata over the last 17 years. General lineal models were used to analyse trends.

Results: Between 1999 and 2015, 6656 HFs occurred in patients with RA of all ages (84.25% women, mean age 77.5 and 15.75% men, mean age 76.37). The age-adjusted osteoporotic HF rate was 221.85/100 000 RA persons/ year (women 227.97; men 179.06). The HF incidence rate increased yearly by 3.1% (95% CI 2.1 to 4.0) during the 1999-2015 period (p<0.001) and was more pronounced in men (3.5% (95% CI 2.1 to 4.9)) than in women (3.1% (95% CI 2.3 to 4.1)). The female to male ratio decreased from 1.54 in 1999 to 1.14 in 2015. The average length of hospital stays (ALHS) decreased (p<0.001) from 16.76 days (SD 15.3) in 1999 to 10.78 days (SD 7.72) in 2015. Age at the time of hospitalisation increased (p<0.001) from 75.3 years (SD 9.33) in 1999 to 79.92 years (SD 9.47) in 2015. There was a total of 326 (4.9%) deaths during admission, 247 (4.4%) in women and 79 (7.5%) in men (p<0.001).

Conclusion: In Spain, despite the advances that have taken place in controlling disease activity and in treating osteoporosis, the incidence rate of HF increased in both male and female patients with RA.

Keywords: Hip fracture; Osteoporosis; Rheumatoid arthritis; Trend.

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Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
Age-adjusted hospital admission rate (HAR) (per 100 000 RA patients/year) during 1999–2015. RA, rheumatoid arthritis.
Figure 2
Figure 2
Hospital admission rate (HAR) of hip fractures (per 100 000 RA patients/year) by age range and sex. RA, rheumatoid arthritis.
Figure 3
Figure 3
Trend of age and average length of hospital stay (ALHS) during 1999–2015.
See this image and copyright information in PMC

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References

    1. Smolen JS, Aletaha D, McInnes IB. Rheumatoid arthritis. Lancet 2016;388:2023–38. 10.1016/S0140-6736(16)30173-8 - DOI - PubMed
    1. Kvien TK. Epidemiology and burden of illness of rheumatoid arthritis. Pharmacoeconomics 2004;22(2 Suppl 1):1–12. 10.2165/00019053-200422001-00002 - DOI - PubMed
    1. Haugeberg G, Uhlig T, Falch JA, et al. . Bone mineral density and frequency of osteoporosis in female patients with rheumatoid arthritis: results from 394 patients in the Oslo County Rheumatoid Arthritis register. Arthritis Rheum 2000;43:522–30. 10.1002/1529-0131(200003)43:3&lt;522::AID-ANR7&gt;3.0.CO;2-Y - DOI - PubMed
    1. Haugeberg G, Uhlig T, Falch JA, et al. . Reduced bone mineral density in male rheumatoid arthritis patients: frequencies and associations with demographic and disease variables in ninety-four patients in the Oslo County Rheumatoid Arthritis Register. Arthritis Rheum 2000;43:2776–84. 10.1002/1529-0131(200012)43:12&lt;2776::AID-ANR18&gt;3.0.CO;2-N - DOI - PubMed
    1. van Staa TP, Geusens P, Bijlsma JW, et al. . Clinical assessment of the long-term risk of fracture in patients with rheumatoid arthritis. Arthritis Rheum 2006;54:3104–12. 10.1002/art.22117 - DOI - PubMed

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