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Case Reports
. 2017 May 9:2017:6952634.
doi: 10.1155/2017/6952634. eCollection 2017.

Injection-Site Sarcoma in a Dog: Clinical and Pathological Findings

Terry M Jacobs  1 , Cathy E Poehlmann  1 , Matti Kiupel  2
Affiliations
Case Reports

Injection-Site Sarcoma in a Dog: Clinical and Pathological Findings

Terry M Jacobs et al. Case Rep Vet Med. .

Abstract

This case report documents the clinical and pathological findings in a dog that rapidly developed a high-grade sarcoma at the site of multiple vaccinations and follows the response to surgery and adjunct treatment with toceranib. An 11-year-old female spayed Labrador Retriever presented with dorsocervical subcutaneous masses at the injection site three weeks after receiving DA2PP-Lepto, Rabies, and Bordetella vaccinations. A high-grade soft tissue sarcoma was diagnosed microscopically and immunohistochemistry revealed positive expression of VEGFr, PDGFr, SCF, and EGFR. Repeat surgical resections and targeted treatment with toceranib resulted in a stable remission for nearly two years.

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Figures

Figure 1
Figure 1
Dorsocervical subcutaneous masses in a dog who received three vaccinations at this site three weeks previously.
Figure 2
Figure 2
Photomicrograph of a soft tissue sarcoma at an injection site in a dog. Hematoxylin and eosin stain.
Figure 3
Figure 3
Positive immunohistochemical staining of the tumor for (a) VEGFr and (b) PDGFr.
See this image and copyright information in PMC

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