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Editorial
. 2018 Apr;6(7):130.
doi: 10.21037/atm.2018.02.20.

Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibition with evolocumab: powerful low-density lipoprotein cholesterol (LDL-C) lowering and improved cardiovascular outcomes without an increase in the risk of diabetes mellitus

Affiliations
Editorial

Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibition with evolocumab: powerful low-density lipoprotein cholesterol (LDL-C) lowering and improved cardiovascular outcomes without an increase in the risk of diabetes mellitus

Constantine E Kosmas et al. Ann Transl Med. 2018 Apr.
No abstract available

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Conflict of interest statement

Conflicts of Interest: CE Kosmas has received personal fees from Amgen, Inc. (Member of the Speaker Bureau) and Sanofi US (Consultant). The other authors have no conflicts of interest to declare.

Comment on

References

    1. Roth GA, Johnson C, Abajobir A, et al. Global, Regional, and National Burden of Cardiovascular Diseases for 10 Causes, 1990 to 2015. J Am Coll Cardiol 2017;70:1-25. 10.1016/j.jacc.2017.04.052 - DOI - PMC - PubMed
    1. Writing Group Members , Mozaffarian D, Benjamin EJ, et al. Heart Disease and Stroke Statistics-2016 Update: A Report From the American Heart Association. Circulation 2016;133:e38-360. 10.1161/CIR.0000000000000350 - DOI - PubMed
    1. O’Keefe JH, Jr, Cordain L, Harris WH, et al. Optimal low-density lipoprotein is 50 to 70 mg/dl: lower is better and physiologically normal. J Am Coll Cardiol 2004;43:2142-46. 10.1016/j.jacc.2004.03.046 - DOI - PubMed
    1. LaRosa JC, Grundy SM, Waters DD, et al. Intensive lipid lowering with atorvastatin in patients with stable coronary disease. N Engl J Med 2005;352:1425-35. 10.1056/NEJMoa050461 - DOI - PubMed
    1. Waters DD. What the statin trials have taught us. Am J Cardiol 2006;98:129-34. 10.1016/j.amjcard.2006.01.066 - DOI - PubMed

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