Measuring cognition and function in the preclinical stage of Alzheimer's disease

doi:10.1016/j.trci.2018.01.003

Review

. 2018 Feb 13:4:64-75.

doi: 10.1016/j.trci.2018.01.003. eCollection 2018.

Measuring cognition and function in the preclinical stage of Alzheimer's disease

Sandra Weintraub^{1

2}, Maria C Carrillo³, Sarah Tomaszewski Farias⁴, Terry E Goldberg⁵, James A Hendrix³, Judith Jaeger^{6

7}, David S Knopman⁸, Jessica B Langbaum⁹, Denise C Park¹⁰, Michael T Ropacki¹¹, Sietske A M Sikkes^{12

13}, Kathleen A Welsh-Bohmer¹⁴, Lisa J Bain¹⁵, Robert Brashear¹⁶, Kumar Budur¹⁷, Ana Graf¹⁸, Ferenc Martenyi¹⁹, Marta Segardahl Storck²⁰, Christopher Randolph^{21

22}

Affiliations

¹ Cognitive Neurology and Alzheimer's Disease Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
² Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
³ Alzheimer's Association, Chicago, IL, USA.
⁴ University of California Davis, Sacramento, CA, USA.
⁵ Division of Geriatric Psychiatry, New York, NY, USA.
⁶ Cognition Metrics, LLC, Wilmington, DE, USA.
⁷ Albert Einstein College of Medicine, Bronx, NY, USA.
⁸ Mayo Clinic College of Medicine, Rochester, MN, USA.
⁹ Banner Alzheimer's Institute, Phoenix, AZ, USA.
¹⁰ The University of Texas at Dallas, Dallas, TX, USA.
¹¹ MedAvante, Hamilton, NJ, USA.
¹² Alzheimer Center, VU University Medical Center, Amsterdam, Netherlands.
¹³ Amsterdam Neuroscience, Amsterdam, Netherlands.
¹⁴ Duke University, Durham, NC, USA.
¹⁵ Independent Science Writer, Elverson, PA, USA.
¹⁶ Janssen Research and Development, Titusville, New Jersey, USA.
¹⁷ AbbVie Inc., North Chicago, Illinois, USA.
¹⁸ Novartis Pharma AG, Basel, Switzerland.
¹⁹ F. Hoffmann-La Roche Ltd, Basel, Switzerland.
²⁰ Lundbeck Pharma, Copenhagen, Denmark.
²¹ MedAvante-Prophase, Hamilton, NJ, USA.
²² Department of Neurology, Loyola University Medical Center, Maywood, IL, USA.

PMID: 29955653
PMCID: PMC6021264
DOI: 10.1016/j.trci.2018.01.003

Review

Measuring cognition and function in the preclinical stage of Alzheimer's disease

Sandra Weintraub et al. Alzheimers Dement (N Y). 2018.

. 2018 Feb 13:4:64-75.

doi: 10.1016/j.trci.2018.01.003. eCollection 2018.

Authors

Affiliations

¹ Cognitive Neurology and Alzheimer's Disease Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
² Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
³ Alzheimer's Association, Chicago, IL, USA.
⁴ University of California Davis, Sacramento, CA, USA.
⁵ Division of Geriatric Psychiatry, New York, NY, USA.
⁶ Cognition Metrics, LLC, Wilmington, DE, USA.
⁷ Albert Einstein College of Medicine, Bronx, NY, USA.
⁸ Mayo Clinic College of Medicine, Rochester, MN, USA.
⁹ Banner Alzheimer's Institute, Phoenix, AZ, USA.
¹⁰ The University of Texas at Dallas, Dallas, TX, USA.
¹¹ MedAvante, Hamilton, NJ, USA.
¹² Alzheimer Center, VU University Medical Center, Amsterdam, Netherlands.
¹³ Amsterdam Neuroscience, Amsterdam, Netherlands.
¹⁴ Duke University, Durham, NC, USA.
¹⁵ Independent Science Writer, Elverson, PA, USA.
¹⁶ Janssen Research and Development, Titusville, New Jersey, USA.
¹⁷ AbbVie Inc., North Chicago, Illinois, USA.
¹⁸ Novartis Pharma AG, Basel, Switzerland.
¹⁹ F. Hoffmann-La Roche Ltd, Basel, Switzerland.
²⁰ Lundbeck Pharma, Copenhagen, Denmark.
²¹ MedAvante-Prophase, Hamilton, NJ, USA.
²² Department of Neurology, Loyola University Medical Center, Maywood, IL, USA.

PMID: 29955653
PMCID: PMC6021264
DOI: 10.1016/j.trci.2018.01.003

Abstract

The Alzheimer's Association's Research Roundtable met in November 2016 to explore how best to measure changes in cognition and function in the preclinical stage of Alzheimer's disease. This review will cover the tools and instruments currently available to identify populations for prevention trials, and measure subtle disease progression in the earliest stages of Alzheimer's disease, and will include discussions of suitable cognitive, behavioral, functional, composite, and biological endpoints for prevention trials. Current prevention trials are reviewed including TOMMOROW, Alzheimer's Prevention Initiative Autosomal Dominant Alzheimer's Disease Trial, the Alzheimer's Prevention Initiative Generation Study, and the Anti-Amyloid Treatment in Asymptomatic Alzheimer's to compare current approaches and tools that are being developed.

PubMed Disclaimer

Figures

**Fig. 1**
Hypothetical interaction of amyloid and tau in preclinical AD. Abbreviations: AD, Alzheimer's disease; MTL, medial temporal lobe.

See this image and copyright information in PMC

Cited by

Cognitive and biological effects of citrus phytochemicals in subjective cognitive decline: a 36-week, randomized, placebo-controlled trial.
Galluzzi S, Zanardini R, Ferrari C, Gipponi S, Passeggia I, Rampini M, Sgrò G, Genovese S, Fiorito S, Palumbo L, Pievani M, Frisoni GB, Epifano F. Galluzzi S, et al. Nutr J. 2022 Oct 17;21(1):64. doi: 10.1186/s12937-022-00817-6. Nutr J. 2022. PMID: 36253765 Free PMC article. Clinical Trial.
Feasibility and reliability of online vs in-person cognitive testing in healthy older people.
Morrissey S, Gillings R, Hornberger M. Morrissey S, et al. PLoS One. 2024 Aug 20;19(8):e0309006. doi: 10.1371/journal.pone.0309006. eCollection 2024. PLoS One. 2024. PMID: 39163365 Free PMC article.
The "rights" of precision drug development for Alzheimer's disease.
Cummings J, Feldman HH, Scheltens P. Cummings J, et al. Alzheimers Res Ther. 2019 Aug 31;11(1):76. doi: 10.1186/s13195-019-0529-5. Alzheimers Res Ther. 2019. PMID: 31470905 Free PMC article. Review.
Modification of everyday activities and its association with self-awareness in cognitively diverse older adults.
Shaked D, Sunderaraman P, Piscitello J, Cines S, Hale C, Devanand D, Karlawish J, Cosentino S. Shaked D, et al. PLoS One. 2019 Nov 7;14(11):e0222769. doi: 10.1371/journal.pone.0222769. eCollection 2019. PLoS One. 2019. PMID: 31697690 Free PMC article.
Developing a Spatial Navigation Screening Tool Sensitive to the Preclinical Alzheimer Disease Continuum.
Allison SL, Rodebaugh TL, Johnston C, Fagan AM, Morris JC, Head D. Allison SL, et al. Arch Clin Neuropsychol. 2019 Oct 24;34(7):1138-1155. doi: 10.1093/arclin/acz019. Arch Clin Neuropsychol. 2019. PMID: 31197326 Free PMC article.

See all "Cited by" articles

References

1. Park D.C., Lautenschlager G., Hedden T., Davidson N.S., Smith A.D., Smith P.K. Models of visuospatial and verbal memory across the adult life span. Psychol Aging. 2002;17:299–320. - PubMed
1. Park D.C., Reuter-Lorenz P. The adaptive brain: aging and neurocognitive scaffolding. Annu Rev Psychol. 2009;60:173–196. - PMC - PubMed
1. Mormino E.C., Kluth J.T., Madison C.M., Rabinovici G.D., Baker S.L., Miller B.L. Episodic memory loss is related to hippocampal-mediated beta-amyloid deposition in elderly subjects. Brain. 2009;132(Pt 5):1310–1323. - PMC - PubMed
1. Rodrigue K.M., Kennedy K.M., Devous M.D., Sr., Rieck J.R., Hebrank A.C., Diaz-Arrastia R. beta-Amyloid burden in healthy aging: regional distribution and cognitive consequences. Neurology. 2012;78:387–395. - PMC - PubMed
1. Holtzman D.M., Herz J., Bu G. Apolipoprotein E and apolipoprotein E receptors: normal biology and roles in Alzheimer disease. Cold Spring Harb Perspect Med. 2012;2:a006312. - PMC - PubMed

Publication types

Actions

Grants and funding

RF1 AG006265/AG/NIA NIH HHS/United States

LinkOut - more resources

Full Text Sources
Other Literature Sources
- The Lens - Patent Citations Database
- scite Smart Citations
Medical
- ClinicalTrials.gov
Miscellaneous
- NCI CPTAC Assay Portal

[1] Park D.C., Lautenschlager G., Hedden T., Davidson N.S., Smith A.D., Smith P.K. Models of visuospatial and verbal memory across the adult life span. Psychol Aging. 2002;17:299–320. - PubMed

[2] Park D.C., Lautenschlager G., Hedden T., Davidson N.S., Smith A.D., Smith P.K. Models of visuospatial and verbal memory across the adult life span. Psychol Aging. 2002;17:299–320. - PubMed

[3] Park D.C., Reuter-Lorenz P. The adaptive brain: aging and neurocognitive scaffolding. Annu Rev Psychol. 2009;60:173–196. - PMC - PubMed

[4] Park D.C., Reuter-Lorenz P. The adaptive brain: aging and neurocognitive scaffolding. Annu Rev Psychol. 2009;60:173–196. - PMC - PubMed

[5] Mormino E.C., Kluth J.T., Madison C.M., Rabinovici G.D., Baker S.L., Miller B.L. Episodic memory loss is related to hippocampal-mediated beta-amyloid deposition in elderly subjects. Brain. 2009;132(Pt 5):1310–1323. - PMC - PubMed

[6] Mormino E.C., Kluth J.T., Madison C.M., Rabinovici G.D., Baker S.L., Miller B.L. Episodic memory loss is related to hippocampal-mediated beta-amyloid deposition in elderly subjects. Brain. 2009;132(Pt 5):1310–1323. - PMC - PubMed

[7] Rodrigue K.M., Kennedy K.M., Devous M.D., Sr., Rieck J.R., Hebrank A.C., Diaz-Arrastia R. beta-Amyloid burden in healthy aging: regional distribution and cognitive consequences. Neurology. 2012;78:387–395. - PMC - PubMed

[8] Rodrigue K.M., Kennedy K.M., Devous M.D., Sr., Rieck J.R., Hebrank A.C., Diaz-Arrastia R. beta-Amyloid burden in healthy aging: regional distribution and cognitive consequences. Neurology. 2012;78:387–395. - PMC - PubMed

[9] Holtzman D.M., Herz J., Bu G. Apolipoprotein E and apolipoprotein E receptors: normal biology and roles in Alzheimer disease. Cold Spring Harb Perspect Med. 2012;2:a006312. - PMC - PubMed

[10] Holtzman D.M., Herz J., Bu G. Apolipoprotein E and apolipoprotein E receptors: normal biology and roles in Alzheimer disease. Cold Spring Harb Perspect Med. 2012;2:a006312. - PMC - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Measuring cognition and function in the preclinical stage of Alzheimer's disease

Affiliations

Measuring cognition and function in the preclinical stage of Alzheimer's disease

Authors

Affiliations

Abstract

Figures

Similar articles

Cited by

References

Publication types

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Miscellaneous