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. 2018 Jul-Sep;40(3):278-286.
doi: 10.1590/2175-8239-jbn-3931. Epub 2018 Jun 21.

Probiotics in the treatment of chronic kidney disease: a systematic review

[Article in English, Portuguese]
Raquel Aparecida Bandeira Fagundes  1 , Taís Fátima Soder  1 , Kamila Castro Grokoski  2 , Fábia Benetti  1 , Roberta Hack Mendes  1
Affiliations

Probiotics in the treatment of chronic kidney disease: a systematic review

[Article in English, Portuguese]
Raquel Aparecida Bandeira Fagundes et al. J Bras Nefrol. 2018 Jul-Sep.

Abstract
in English, Portuguese

Chronic kidney disease (CKD) is a syndrome caused by the progressive reduction of renal function. This study aimed to systematically examine the effects of supplementation with probiotics in the treatment of CKD. Searches were carried out on databases MEDLINE (PubMed), SciELO, Cochrane, and Clinical Trials. Two independent reviewers selected the studies from which data was extracted. The search included papers written in English and Portuguese published in the 2012-2016 period describing randomized clinical trials. Eight of the 82 eligible articles met the inclusion criteria. Sample size ranged from 18 to 101 individuals with CKD. The duration of the included studies varied from four to 24 weeks. Most of the included articles reported positive effects in renal function and decreased levels of urea, blood urea nitrogen, ammonia, plasma p-cresol, p-cresyl sulfate, and indoxyl sulfate.

A insuficiência renal crônica (IRC) é definida como uma síndrome causada pela redução progressiva da função renal. O objetivo deste trabalho foi revisar sistematicamente o efeito da suplementação probiótica no tratamento da IRC. Foi realizada uma busca nas bases de dados MEDLINE (PubMed), SciELO, Cochrane e Clinical Trials. Dois revisores independentes realizaram a seleção dos estudos e a extração de dados. A pesquisa incluiu estudos entre 2012-2016, do tipo estudo clínico randomizado, em inglês e em português. Dos 82 artigos elegíveis, 8 artigos preencheram os critérios de inclusão. O número amostral variou de 18 a 101 pacientes com IRC, com duração de 4 a 24 semanas de estudo. A maioria dos estudos relatados mostraram efeitos benéficos na redução das concentrações de ureia, nitrogênio ureico, amônia, p-cresol plasmático, sulfato de p-cresil e sulfato de indoxil, ou seja, os probióticos parecem estar relacionados à melhora da função de renal.

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Figures

Figure 1
Figure 1. Flowchart describing the identification and selection of articles (PRISMA).
See this image and copyright information in PMC

References

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