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. 2018 Jun 29;7(1):120.
doi: 10.1038/s41426-018-0119-9.

Xapuri virus, a novel mammarenavirus: natural reassortment and increased diversity between New World viruses

Jorlan Fernandes  1 , Alexandro Guterres  2 , Renata Carvalho de Oliveira  2 , John Chamberlain  3 , Kuiama Lewandowski  3 , Bernardo Rodrigues Teixeira  4 , Thayssa Alves Coelho  2 , Charle Ferreira Crisóstomo  4   5   6 , Cibele Rodrigues Bonvicino  4   7 , Paulo Sérgio D'Andrea  4   6 , Roger Hewson  3 , Elba Regina Sampaio de Lemos  8
Affiliations

Xapuri virus, a novel mammarenavirus: natural reassortment and increased diversity between New World viruses

Jorlan Fernandes et al. Emerg Microbes Infect. .

Abstract

Mammarenavirus RNA was detected in Musser's bristly mouse (Neacomys musseri) from the Amazon region, and this detection indicated that rodents were infected with a novel mammarenavirus, with the proposed name Xapuri virus (XAPV), which is phylogenetically related to New World Clade B and Clade C viruses. XAPV may represent the first natural reassortment of the Arenaviridae family and a new unrecognized clade within the Tacaribe serocomplex group.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
Municipalities of Acre state, Brazil, in which rodents were captured
Fig. 2
Fig. 2
Xapuri mammarenavirus genome organization and potential secondary structure of intergenic regions
Fig. 3
Fig. 3. Phylogenetic tree based on the mammarenavirus complete L segments, with ML and Bayesian methods, using the evolutionary model GTR + G + l
. Numbers (≥0.7/≥70) above branches indicate node probabilities or bootstrap values (MrBayes/ML). Asterisks indicate values below 0.7/70. Sequences from this study are highlighted in bold
Fig. 4
Fig. 4. Phylogenetic tree based on the mammarenavirus complete S segments, with ML and Bayesian methods, using the evolutionary model GTR + G + l
. Numbers (≥0.7/≥70) above branches indicate node probabilities or bootstrap values (MrBayes/ML). Asterisks indicate values below 0.7/70. Sequences from this study are highlighted in bold
Fig. 5
Fig. 5. Phylogenetic trees based on the complete NP, GPC, Z, and L mammarenavirus proteins, using ML and Bayesian methods, (Z protein) complete Z, using the evolutionary model RtREV + G + I, (RdRp protein) complete L, using the evolutionary model LG + G + I, (GPC protein) complete GPC, using the evolutionary model LG + G + I, and (NP protein) complete NP, using the evolutionary model.
Numbers (≥0.7/≥70) above branches indicate node probabilities or bootstrap values (MrBayes/ML). Asterisks indicate values below 0.7/70. †Exhibited a difference between ML and MrBayes tree-building method topologies. Sequences from this study are highlighted in bold
See this image and copyright information in PMC

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References

    1. Radoshitzky SR, et al. Past, present, and future of arenavirus taxonomy. Arch. Virol. 2015;160:1851–1874. doi: 10.1007/s00705-015-2418-y. - DOI - PubMed
    1. Sayler KA, et al. Isolation of tacaribe virus, a caribbean arenavirus, from host-seeking amblyomma americanum ticks in Florida. PLoS ONE. 2014;9:1–16. doi: 10.1371/journal.pone.0115769. - DOI - PMC - PubMed
    1. Li K, et al. Isolation and characterization of a novel arenavirus harbored by Rodents and Shrews in Zhejiang province, China. Virology. 2015;476:37–42. doi: 10.1016/j.virol.2014.11.026. - DOI - PubMed
    1. Maes, P. et al. Taxonomy of the family Arenaviridae and the order Bunyavirales: update 2018. Arch. Virol. 10.1007/s00705-018-3843-5, 1–16 (2018). - PubMed
    1. Charrel RN, de Lamballerie X, Emonet S. Phylogeny of the genus Arenavirus. Curr. Opin. Microbiol. 2008;11:362–368. doi: 10.1016/j.mib.2008.06.001. - DOI - PubMed

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