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. 2018 Jun 29;7(1):120.
doi: 10.1038/s41426-018-0119-9.

Xapuri virus, a novel mammarenavirus: natural reassortment and increased diversity between New World viruses

Jorlan Fernandes  1 , Alexandro Guterres  2 , Renata Carvalho de Oliveira  2 , John Chamberlain  3 , Kuiama Lewandowski  3 , Bernardo Rodrigues Teixeira  4 , Thayssa Alves Coelho  2 , Charle Ferreira Crisóstomo  4   5   6 , Cibele Rodrigues Bonvicino  4   7 , Paulo Sérgio D'Andrea  4   6 , Roger Hewson  3 , Elba Regina Sampaio de Lemos  8
Affiliations

Xapuri virus, a novel mammarenavirus: natural reassortment and increased diversity between New World viruses

Jorlan Fernandes et al. Emerg Microbes Infect. .

Abstract

Mammarenavirus RNA was detected in Musser's bristly mouse (Neacomys musseri) from the Amazon region, and this detection indicated that rodents were infected with a novel mammarenavirus, with the proposed name Xapuri virus (XAPV), which is phylogenetically related to New World Clade B and Clade C viruses. XAPV may represent the first natural reassortment of the Arenaviridae family and a new unrecognized clade within the Tacaribe serocomplex group.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
Municipalities of Acre state, Brazil, in which rodents were captured
Fig. 2
Fig. 2
Xapuri mammarenavirus genome organization and potential secondary structure of intergenic regions
Fig. 3
Fig. 3. Phylogenetic tree based on the mammarenavirus complete L segments, with ML and Bayesian methods, using the evolutionary model GTR + G + l
. Numbers (≥0.7/≥70) above branches indicate node probabilities or bootstrap values (MrBayes/ML). Asterisks indicate values below 0.7/70. Sequences from this study are highlighted in bold
Fig. 4
Fig. 4. Phylogenetic tree based on the mammarenavirus complete S segments, with ML and Bayesian methods, using the evolutionary model GTR + G + l
. Numbers (≥0.7/≥70) above branches indicate node probabilities or bootstrap values (MrBayes/ML). Asterisks indicate values below 0.7/70. Sequences from this study are highlighted in bold
Fig. 5
Fig. 5. Phylogenetic trees based on the complete NP, GPC, Z, and L mammarenavirus proteins, using ML and Bayesian methods, (Z protein) complete Z, using the evolutionary model RtREV + G + I, (RdRp protein) complete L, using the evolutionary model LG + G + I, (GPC protein) complete GPC, using the evolutionary model LG + G + I, and (NP protein) complete NP, using the evolutionary model.
Numbers (≥0.7/≥70) above branches indicate node probabilities or bootstrap values (MrBayes/ML). Asterisks indicate values below 0.7/70. †Exhibited a difference between ML and MrBayes tree-building method topologies. Sequences from this study are highlighted in bold
See this image and copyright information in PMC

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