. 2018 Jun 29;9(1):2537.

doi: 10.1038/s41467-018-04807-3.

Misestimation of heritability and prediction accuracy of male-pattern baldness

Chloe X Yap¹, Julia Sidorenko^{1

2}, Riccardo E Marioni^{3

4}, Loic Yengo¹, Naomi R Wray^{1

5}, Peter M Visscher^{6

7}

Affiliations

¹ Institute for Molecular Bioscience, The University of Queensland, Brisbane, 4072, Australia.
² Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, 51010, Estonia.
³ Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK.
⁴ Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, EH8 9JZ, UK.
⁵ Queensland Brain Institute, The University of Queensland, Brisbane, 4072, Australia.
⁶ Institute for Molecular Bioscience, The University of Queensland, Brisbane, 4072, Australia. peter.visscher@uq.edu.au.
⁷ Queensland Brain Institute, The University of Queensland, Brisbane, 4072, Australia. peter.visscher@uq.edu.au.

PMID: 29959328
PMCID: PMC6026149
DOI: 10.1038/s41467-018-04807-3

Misestimation of heritability and prediction accuracy of male-pattern baldness

Chloe X Yap et al. Nat Commun. 2018.

. 2018 Jun 29;9(1):2537.

doi: 10.1038/s41467-018-04807-3.

Authors

Chloe X Yap¹, Julia Sidorenko^{1

2}, Riccardo E Marioni^{3

4}, Loic Yengo¹, Naomi R Wray^{1

5}, Peter M Visscher^{6

7}

Affiliations

¹ Institute for Molecular Bioscience, The University of Queensland, Brisbane, 4072, Australia.
² Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, 51010, Estonia.
³ Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK.
⁴ Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, EH8 9JZ, UK.
⁵ Queensland Brain Institute, The University of Queensland, Brisbane, 4072, Australia.
⁶ Institute for Molecular Bioscience, The University of Queensland, Brisbane, 4072, Australia. peter.visscher@uq.edu.au.
⁷ Queensland Brain Institute, The University of Queensland, Brisbane, 4072, Australia. peter.visscher@uq.edu.au.

PMID: 29959328
PMCID: PMC6026149
DOI: 10.1038/s41467-018-04807-3

Erratum in

Author Correction: Misestimation of heritability and prediction accuracy of male-pattern baldness.
Yap CX, Sidorenko J, Marioni RE, Yengo L, Wray NR, Visscher PM. Yap CX, et al. Nat Commun. 2018 Nov 20;9(1):4953. doi: 10.1038/s41467-018-07400-w. Nat Commun. 2018. PMID: 30459399 Free PMC article.

No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

Figures

**Fig. 1**
Trait-increasing allele frequency by MPB score in UKB for 47 genome-wide significant GWAS loci identified in refs. ^–,. For each of the 47 loci, the trait-increasing allele frequency in the UK Biobank sample is given on the y-axis, as a deviation from its frequency for men with a MPB score of 1. The x-axis labels represent the observed MPB categories in the UK Biobank

See this image and copyright information in PMC

Comment in

Reply to 'Misestimation of heritability and prediction accuracy of male-pattern baldness'.
Pirastu N, Joshi PK, de Vries PS, Cornelis MC, Keum N, Franceschini N, Colombo M, Giovannucci EL, Spiliopoulou A, Franke L, North KE, Kraft P, Morrison AC, Esko T, Wilson JF. Pirastu N, et al. Nat Commun. 2018 Jun 29;9(1):2538. doi: 10.1038/s41467-018-04808-2. Nat Commun. 2018. PMID: 29959316 Free PMC article. No abstract available.

Cited by

Exploring the genetic heterogeneity in major depression across diagnostic criteria.
Jermy BS, Glanville KP, Coleman JRI, Lewis CM, Vassos E. Jermy BS, et al. Mol Psychiatry. 2021 Dec;26(12):7337-7345. doi: 10.1038/s41380-021-01231-w. Epub 2021 Jul 21. Mol Psychiatry. 2021. PMID: 34290369 Free PMC article.
Genetic heterogeneity and subtypes of major depression.
Nguyen TD, Harder A, Xiong Y, Kowalec K, Hägg S, Cai N, Kuja-Halkola R, Dalman C, Sullivan PF, Lu Y. Nguyen TD, et al. Mol Psychiatry. 2022 Mar;27(3):1667-1675. doi: 10.1038/s41380-021-01413-6. Epub 2022 Jan 8. Mol Psychiatry. 2022. PMID: 34997191 Free PMC article.
A large population-based investigation into the genetics of susceptibility to gastrointestinal infections and the link between gastrointestinal infections and mental illness.
Nudel R, Appadurai V, Schork AJ, Buil A, Bybjerg-Grauholm J, Børglum AD, Daly MJ, Mors O, Hougaard DM, Mortensen PB, Werge T, Nordentoft M, Thompson WK, Benros ME. Nudel R, et al. Hum Genet. 2020 May;139(5):593-604. doi: 10.1007/s00439-020-02140-8. Epub 2020 Mar 9. Hum Genet. 2020. PMID: 32152699 Free PMC article.
Uncovering the genetic architecture and evolutionary roots of androgenetic alopecia in African men.
Janivara R, Hazra U, Pfennig A, Harlemon M, Kim MS, Eaaswarkhanth M, Chen WC, Ogunbiyi A, Kachambwa P, Petersen LN, Jalloh M, Mensah JE, Adjei AA, Adusei B, Joffe M, Gueye SM, Aisuodionoe-Shadrach OI, Fernandez PW, Rohan TE, Andrews C, Rebbeck TR, Adebiyi AO, Agalliu I, Lachance J. Janivara R, et al. bioRxiv [Preprint]. 2024 Jan 15:2024.01.12.575396. doi: 10.1101/2024.01.12.575396. bioRxiv. 2024. Update in: HGG Adv. 2025 Jul 10;6(3):100428. doi: 10.1016/j.xhgg.2025.100428. PMID: 38293167 Free PMC article. Updated. Preprint.
Insights into the genetic basis of retinal detachment.
Boutin TS, Charteris DG, Chandra A, Campbell S, Hayward C, Campbell A; UK Biobank Eye & Vision Consortium; Nandakumar P, Hinds D; 23andMe Research Team; Mitry D, Vitart V. Boutin TS, et al. Hum Mol Genet. 2020 Mar 13;29(4):689-702. doi: 10.1093/hmg/ddz294. Hum Mol Genet. 2020. PMID: 31816047 Free PMC article.

See all "Cited by" articles

References

1. Pirastu N, et al. GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk. Nat. Commun. 2017;8:1584. doi: 10.1038/s41467-017-01490-8. - DOI - PMC - PubMed
1. Li R, et al. Six novel susceptibility Loci for early-onset androgenetic alopecia and their unexpected association with common diseases. PLOS Genet. 2012;8:e1002746. doi: 10.1371/journal.pgen.1002746. - DOI - PMC - PubMed
1. Hillmer AM, et al. Susceptibility variants for male-pattern baldness on chromosome 20p11. Nat. Genet. 2008;40:1279–1281. doi: 10.1038/ng.228. - DOI - PubMed
1. Brockschmidt FF, et al. Susceptibility variants on chromosome 7p21.1 suggest HDAC9 as a new candidate gene for male-pattern baldness. Br. J. Dermatol. 2011;165:1293–1302. doi: 10.1111/j.1365-2133.2011.10708.x. - DOI - PubMed
1. Richards JB, et al. Male-pattern baldness susceptibility locus at 20p11. Nat. Genet. 2008;40:1282–1284. doi: 10.1038/ng.255. - DOI - PMC - PubMed

Publication types

Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Grants and funding

LinkOut - more resources

Full Text Sources
Other Literature Sources
- scite Smart Citations

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Misestimation of heritability and prediction accuracy of male-pattern baldness

Affiliations

Misestimation of heritability and prediction accuracy of male-pattern baldness

Authors

Affiliations

Erratum in

Conflict of interest statement

Figures

Comment in

Similar articles

Cited by

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources