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Multicenter Study
. 2019 Jan 7;68(2):334-337.
doi: 10.1093/cid/ciy525.

Rapid and Extensive Expansion in the United States of a New Multidrug-resistant Escherichia coli Clonal Group, Sequence Type 1193

Veronika L Tchesnokova  1 , Elena Rechkina  2 , Lydia Larson  1 , Kendra Ferrier  1 , Jamie Lee Weaver  1 , David W Schroeder  1 , Rosemary She  3 , Susan M Butler-Wu  3 , Maria E Aguero-Rosenfeld  4 , Danielle Zerr  5 , Ferric C Fang  6 , James Ralston  7   8 , Kim Riddell  7 , Delia Scholes  7   8 , Scott Weissman  5 , Kaveri Parker  2 , Brad Spellberg  3 , James R Johnson  9 , Evgeni V Sokurenko  1
Affiliations
Multicenter Study

Rapid and Extensive Expansion in the United States of a New Multidrug-resistant Escherichia coli Clonal Group, Sequence Type 1193

Veronika L Tchesnokova et al. Clin Infect Dis. .

Abstract

We describe the rapid and ongoing emergence across multiple US cities of a new multidrug-resistant Escherichia coli clone-sequence type (ST) 1193-resistant to fluoroquinolones (100%), trimethoprim-sulfamethoxazole (55%), and tetracycline (53%). ST1193 is associated with younger adults (age <40 years) and currently comprises a quarter of fluoroquinolone-resistant clinical E. coli urine isolates.

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References

    1. Price LB, Johnson JR, Aziz M, et al. . The epidemic of extended-spectrum-β-lactamase-producing Escherichia coli ST131 is driven by a single highly pathogenic subclone, H30-Rx. MBio 2013; 4:e00377–13. - PMC - PubMed
    1. Jørgensen S, Sunde M, Berg E, et al. Fluoroquinolone resistant Escherichia coli ST1193 – another global successful clone? 27th ECCMID 2017; P0204.
    1. Kim Y, Oh T, Nam YS, Cho SY, Lee HJ. Prevalence of ST131 and ST1193 among bloodstream isolates of Escherichia coli not susceptible to ciprofloxacin in a tertiary care university hospital in Korea, 2013–2014. Clin Lab 2017; 63:1541–3. - PubMed
    1. Platell JL, Trott DJ, Johnson JR, et al. . Prominence of an O75 clonal group (clonal complex 14) among non-ST131 fluoroquinolone-resistant Escherichia coli causing extraintestinal infections in humans and dogs in Australia. Antimicrob Agents Chemother 2012; 56:3898–904. - PMC - PubMed
    1. Wu J, Lan F, Lu Y, He Q, Li B. Molecular characteristics of ST1193 clone among phylogenetic group B2 non-ST131 fluoroquinolone-resistant Escherichia coli. Front Microbiol 2017; 8:2294. - PMC - PubMed

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