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Review
. 2018 Jun 28;24(24):2555-2566.
doi: 10.3748/wjg.v24.i24.2555.

Hepatitis C virus infection in children in the era of direct-acting antiviral

Malgorzata Pawlowska  1 , Malgorzata Sobolewska-Pilarczyk  2 , Krzysztof Domagalski  3
Affiliations
Review

Hepatitis C virus infection in children in the era of direct-acting antiviral

Malgorzata Pawlowska et al. World J Gastroenterol. .

Abstract

Hepatitis C virus (HCV) infection remains an important global health problem with chronic infection affecting approximately 11 million children worldwide. The emergence of direct-acting antiviral (DAA) therapies and the development of non-invasive methods for the determination of liver fibrosis will significantly improve the management of paediatric patients with chronic HCV infection in subsequent years. For paediatric patients, a new era of highly effective DAA agents is beginning, and the first results of available clinical trials are very promising. In this era, the identification and monitoring of patients continues to be an important issue. The availability of non-invasive serological and imaging methods to measure hepatic fibrosis enables the identification of patients with significant or advanced liver fibrosis stages. This article summarizes the current data on the epidemiology and progress of research aimed to evaluate the new therapies and non-invasive methods for liver injury in paediatric patients with chronic hepatitis C.

Keywords: Adolescents; Biomarkers of liver injury; Children; Direct-acting antiviral; Epidemiology; Hepatitis C virus; Non-invasive methods.

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Conflict of interest statement

Conflict-of-interest statement: The authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
Recommended treatment of hepatitis C virus infected children. HCV: Hepatitis C virus.
See this image and copyright information in PMC

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References

    1. Khaderi S, Shepherd R, Goss JA, Leung DH. Hepatitis C in the pediatric population: transmission, natural history, treatment and liver transplantation. World J Gastroenterol. 2014;20:11281–11286. - PMC - PubMed
    1. Indolfi G, Bartolini E, Casavola D, Resti M. Chronic hepatitis C virus infection in children and adolescents: Epidemiology, natural history, and assessment of the safety and efficacy of combination therapy. Adolesc Health Med Ther. 2010;1:115–128. - PMC - PubMed
    1. Mohd Hanafiah K, Groeger J, Flaxman AD, Wiersma ST. Global epidemiology of hepatitis C virus infection: new estimates of age-specific antibody to HCV seroprevalence. Hepatology. 2013;57:1333–1342. - PubMed
    1. Petruzziello A, Marigliano S, Loquercio G, Cozzolino A, Cacciapuoti C. Global epidemiology of hepatitis C virus infection: An up-date of the distribution and circulation of hepatitis C virus genotypes. World J Gastroenterol. 2016;22:7824–7840. - PMC - PubMed
    1. Shepard CW, Finelli L, Alter MJ. Global epidemiology of hepatitis C virus infection. Lancet Infect Dis. 2005;5:558–567. - PubMed

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