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Clinical Trial
. 1985 Oct;79(4):385-9.
doi: 10.1016/0007-0971(85)90073-7.

Nedocromil, a mucosal and connective tissue mast cell stabilizer, inhibits exercise-induced asthma

R J Shaw, A B Kay
Clinical Trial

Nedocromil, a mucosal and connective tissue mast cell stabilizer, inhibits exercise-induced asthma

R J Shaw et al. Br J Dis Chest. 1985 Oct.

Abstract

Nedocromil, the disodium salt of a pyranoquinoline dicarboxylic acid, has a similar profile of activity to disodium cromoglycate (DSCG) but appears to be more active in stabilizing mucosal-type mast cells. In a double-blind placebo-controlled trial nedocromil (2 mg) was given by inhalation to eight asthmatic patients prior to a treadmill exercise task. There was a significant reduction in the fall in FEV1 (P less than 0.01) and FVC (P less than 0.05) after nedocromil when compared to placebo. This study indicates that nedocromil might be an effective anti-asthma agent and in addition may help define the role of the mucosal mast cell.

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