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Review
. 2018 Jun 29;23(7):1588.
doi: 10.3390/molecules23071588.

Chemical Structures and Biological Activities of Limonoids from the Genus Swietenia (Meliaceae)

Yun-Peng Sun  1 , Wen-Fang Jin  2 , Yong-Yue Wang  3 , Gang Wang  4   5 , Susan L Morris-Natschke  6 , Jin-Song Liu  7   8 , Guo-Kai Wang  9   10   11 , Kuo-Hsiung Lee  12   13
Affiliations
Review

Chemical Structures and Biological Activities of Limonoids from the Genus Swietenia (Meliaceae)

Yun-Peng Sun et al. Molecules. .

Abstract

Swietenia is a genus in the plant family Meliaceae. This genus contains seven to eight known species, found in the tropical and subtropical regions of the Americas and West Africa. Thus far, more than 160 limonoids have been isolated from four species of the genus Swietenia. Limonoids are rich in structure type and biological activity, and these compounds are the main active components in the Swietenia species. This paper will give a comprehensive overview of the recent phytochemical and pharmacological research on the terpenes from Swietenia plants and encourage further drug discovery research.

Keywords: biological activities; chemical components; genus Swietenia; limonoids.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Chemical structures of azadirone-type and evodulon-type limonoids 1–4.
Figure 2
Figure 2
Chemical structures of gedunin-type limonoids 5–13.
Figure 3
Figure 3
Chemical structures of andirobin-type limonoids 14–21.
Figure 4
Figure 4
Chemical structures of mexicanolide-type limonoids 22–98.
Figure 5
Figure 5
Chemical structures of phragmalin-type limonoids 99–153.
Figure 6
Figure 6
Chemical structures of polyoxyphragmalin-type limonoids 154–164.
Figure 7
Figure 7
Chemical structures of limonoids 165–169 from other plants.
See this image and copyright information in PMC

References

    1. Mootoo B.S., Ali A., Motilal R., Pingal R., Ramlal A., Khan A., Reynolds W.F., McLean S. Limonoids from Swietenia macrophylla and S. aubrevilleana. J. Nat. Prod. 1999;62:1514–1517. doi: 10.1021/np990199x. - DOI - PubMed
    1. Panda S.P., Haldar P.K., Bera S., Adhikary S., Kandar C.C. Antidiabetic and antioxidant activity of Swietenia mahagoni in streptozotocin-induced diabetic rats. Pharm. Biol. 2010;48:974–979. doi: 10.3109/13880200903390051. - DOI - PubMed
    1. Dutta M., Biswas U.K., Chakraborty R., Banerjee P., Raychaudhuri U. Regeneration of pancreatic β-cells on streptozotocin induced diabetic rats under the effect of swietenia macrophylla seeds. Int. J. Green Pharm. 2013;6:336–339. doi: 10.4103/0973-8258.108253. - DOI
    1. Dutta M., Biswas U.K., Chakraborty R., Banerjee P., Maji D., Mondal M.C., Raychaudhuri U. Antidiabetic and antioxidant effect of Swietenia macrophylla seeds in experimental type 2 diabetic rats. Int. J. Diabetes Dev. Ctries. 2013;33:60–65. doi: 10.1007/s13410-012-0109-8. - DOI
    1. Dewanjee S., Kundu M., Maiti A., Majumdar R., Majumdar A., Mandel S.C. In vitro evaluation of antimicrobial activity of crude extract from plants Diospyros peregrina, Coccinia grandis and Swietenia macrophylla. Trop. J. Pharm. Res. 2007;6:773–778. doi: 10.4314/tjpr.v6i3.14658. - DOI

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