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. 1985 Nov 4;346(2):404-8.
doi: 10.1016/0006-8993(85)90880-7.

Neuropeptide Y reduces orthodromically evoked population spike in rat hippocampal CA1 by a possibly presynaptic mechanism

W F Colmers, K Lukowiak, Q J Pittman

Neuropeptide Y reduces orthodromically evoked population spike in rat hippocampal CA1 by a possibly presynaptic mechanism

W F Colmers et al. Brain Res. .

Abstract

Application of the brain neuropeptide Y (NPY) to rat hippocampus in vitro reversibly reduced the amplitude of the CA1 population spike evoked by stratum radiatum stimulation. Threshold for the effect was 10(-8) M. NPY had similar effects on single pulse- and paired pulse-evoked population spikes. Antidromic population spikes, evoked from the alveus, were unaffected by NPY. Thus, NPY appears to modulate excitatory transmission in the hippocampus by a presynaptic mechanism.

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