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Editorial
. 2018 Jul 3;138(1):64-66.
doi: 10.1161/CIRCULATIONAHA.118.034454.

Understanding Obesity-Related Cardiovascular Disease: It's All About Balance

Abdalrahman Zarzour  1 , Ha Won Kim  1 , Neal L Weintraub  2
Affiliations
Editorial

Understanding Obesity-Related Cardiovascular Disease: It's All About Balance

Abdalrahman Zarzour et al. Circulation. .
No abstract available

Keywords: Editorials; adipokines; cardiovascular diseases; inflammation; obesity.

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Figures

Figure
Figure. Proposed mechanisms whereby a novel adipokine, FAM19A5, regulates neointima formation
FAM19A5 secreted from healthy adipocytes binds to the S1PR2 receptor in vascular smooth muscle cells (VSMCs), which triggers downstream G12/G13 and RhoA signaling pathway to inhibit VSMC proliferation and migration, thereby protecting against neointima formation. In obesity, impaired FAM19A5 release from dysfunctional adipocytes fails to restrain VSMC growth, thus leading to enhanced neointima formation.
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References

    1. Wang Y, Beydoun MA, Liang L, Caballero B, Kumanyika SK. Will all Americans become overweight or obese? estimating the progression and cost of the US obesity epidemic. Obesity. 2008;16:2323–2330. - PubMed
    1. Ndumele CE, Matsushita K, Lazo M, Bello N, Blumenthal RS, Gerstenblith G, Nambi V, Ballantyne CM, Solomon SD, Selvin E, Folsom AR, Coresh J. Obesity and Subtypes of Incident Cardiovascular Disease. J Am Heart Assoc. 2016;5:e003921. - PMC - PubMed
    1. Hubert HB, Feinleib M, McNamara PM, Castelli WP. Obesity as an independent risk factor for cardiovascular disease: a 26-year follow-up of participants in the Framingham Heart Study. Circulation. 1983;67:968–977. - PubMed
    1. Rocha VZ, Libby P. Obesity, inflammation, and atherosclerosis. Nat Rev Cardiol. 2009;6:399–409. - PubMed
    1. Rogowski O, Shapira I, Toker S, Melamed S, Shirom A, Berliner S, Zeltser D. Obesity-related correlation between C-reactive protein and the calculated 10-y Framingham Coronary Heart Disease Risk Score. Int J Obes. 2005;29:772–777. - PubMed

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