Hypogonadism as a Reversible Cause of Torsades de Pointes in Men

Joe-Elie Salem^{1

2

3

4

5

6

7}, Xavier Waintraub^{2

4}, Carine Courtillot^{8

9}, Christian M Shaffer⁶, Estelle Gandjbakhch^{2

4

5}, Carole Maupain^{2

4}, Javid J Moslehi⁷, Fabio Badilini¹⁰, Julien Haroche^{11

12}, Paul Gougis^{13

3

5}, Veronique Fressart^{2

4}, Andrew M Glazer⁶, Francoise Hidden-Lucet^{2

4}, Philippe Touraine^{8

9

5}, Benedicte Lebrun-Vignes^{13

3

5}, Dan M Roden⁶, Anne Bachelot^{8

9

5}, Christian Funck-Brentano^{13

3

5}

Affiliations

¹ Department of Pharmacology, Pharmacovigilance Unit (J.-E.S., P.G., B.L.-V., C.F.-B.) joe-elie.salem@aphp.fr joe-elie.salem@vanderbilt.edu.
² Department of Cardiology, CIC 1421, Cardiogenetic Unit, Arrhythmology Unit (J.-E.S., X.W., E.G., C.M., V.F., F.H.-L.).
³ Institut National de la Santé et de la Recherche Médicale (J.-E.S., P.G., B.L.-V., C.F.-B.).
⁴ UMR Institute of Cardiometabolism and Nutrition (J.-E.S., X.W., E.G., C.M., V.F., F.H.-L.), Paris, France.
⁵ Sorbonne Université, Faculty of Medicine, Paris, France (J.-E.S., P.G., B.L.-V., C.F.-B., A.B., P.T., E.G.).
⁶ Departments of Medicine, Pharmacology, and Biomedical Informatics (J.-E.S., C.M.S., A.M.G., D.M.R.).
⁷ Departments of Medicine, Cardiology, and Cardio-Oncology Program, Vanderbilt University Medical Center, Nashville, TN (J.-E.S., J.J.M.).
⁸ Department of Endocrinology and Reproductive Medicine (C.C., P.T., A.B.), AP-HP, Pitié-Salpêtrière Hospital, Paris, France.
⁹ Centre de Référence des Maladies Endocriniennes Rares de la Croissance et Centre des Pathologies Gynécologiques Rares (C.C., P.T., A.B.).
¹⁰ AMPS LLC, New York, NY (F.B.).
¹¹ Department of Internal Medicine (J.H.).
¹² Sorbonne Université, Faculty of Medicine, Paris, France (J.H.).
¹³ Department of Pharmacology, Pharmacovigilance Unit (J.-E.S., P.G., B.L.-V., C.F.-B.).

PMID: 29967236
PMCID: PMC6053686
DOI: 10.1161/CIRCULATIONAHA.118.034282

Hypogonadism as a Reversible Cause of Torsades de Pointes in Men

Joe-Elie Salem et al. Circulation. 2018.

. 2018 Jul 3;138(1):110-113.

doi: 10.1161/CIRCULATIONAHA.118.034282.

Authors

Affiliations

¹ Department of Pharmacology, Pharmacovigilance Unit (J.-E.S., P.G., B.L.-V., C.F.-B.) joe-elie.salem@aphp.fr joe-elie.salem@vanderbilt.edu.
² Department of Cardiology, CIC 1421, Cardiogenetic Unit, Arrhythmology Unit (J.-E.S., X.W., E.G., C.M., V.F., F.H.-L.).
³ Institut National de la Santé et de la Recherche Médicale (J.-E.S., P.G., B.L.-V., C.F.-B.).
⁴ UMR Institute of Cardiometabolism and Nutrition (J.-E.S., X.W., E.G., C.M., V.F., F.H.-L.), Paris, France.
⁵ Sorbonne Université, Faculty of Medicine, Paris, France (J.-E.S., P.G., B.L.-V., C.F.-B., A.B., P.T., E.G.).
⁶ Departments of Medicine, Pharmacology, and Biomedical Informatics (J.-E.S., C.M.S., A.M.G., D.M.R.).
⁷ Departments of Medicine, Cardiology, and Cardio-Oncology Program, Vanderbilt University Medical Center, Nashville, TN (J.-E.S., J.J.M.).
⁸ Department of Endocrinology and Reproductive Medicine (C.C., P.T., A.B.), AP-HP, Pitié-Salpêtrière Hospital, Paris, France.
⁹ Centre de Référence des Maladies Endocriniennes Rares de la Croissance et Centre des Pathologies Gynécologiques Rares (C.C., P.T., A.B.).
¹⁰ AMPS LLC, New York, NY (F.B.).
¹¹ Department of Internal Medicine (J.H.).
¹² Sorbonne Université, Faculty of Medicine, Paris, France (J.H.).
¹³ Department of Pharmacology, Pharmacovigilance Unit (J.-E.S., P.G., B.L.-V., C.F.-B.).

PMID: 29967236
PMCID: PMC6053686
DOI: 10.1161/CIRCULATIONAHA.118.034282

No abstract available

Keywords: androgen antagonists; androgens; antineoplastic agents; hypogonadism; men; testosterone; torsades de pointes.

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References

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1. Salem JE, Alexandre J, Bachelot A, Funck-Brentano C. Influence of steroid hormones on ventricular repolarization. Pharmacol Ther. 2016;167:38–47. - PubMed
1. Roden DM, Pulley JM, Basford MA, Bernard GR, Clayton EW, Balser JR, Masys DR. Development of a large-scale de-identified DNA biobank to enable personalized medicine. Clin Pharmacol Ther. 2008;84:362–369. - PMC - PubMed
1. De Bruin ML, Pettersson M, Meyboom RH, Hoes AW, Leufkens HG. Anti-HERG activity and the risk of drug-induced arrhythmias and sudden death. Eur Heart J. 2005;26:590–597. - PubMed
1. Rey RA, Grinspon RP, Gottlieb S, Pasqualini T, Knoblovits P, Aszpis S, Pacenza N, Stewart Usher J, Bergada I, Campo SM. Male hypogonadism: an extended classification based on a developmental, endocrine physiology-based approach. Andrology. 2013;1:3–16. - PubMed

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Hypogonadism as a Reversible Cause of Torsades de Pointes in Men

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Hypogonadism as a Reversible Cause of Torsades de Pointes in Men

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