Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Jun 18:9:330.
doi: 10.3389/fendo.2018.00330. eCollection 2018.

Correlation Between Oral Lichen Planus and Thyroid Disease in China: A Case-Control Study

Tingting Zhou  1 , Dan Li  1 , Qianming Chen  2 , Hong Hua  1 , Chunlei Li  1
Affiliations

Correlation Between Oral Lichen Planus and Thyroid Disease in China: A Case-Control Study

Tingting Zhou et al. Front Endocrinol (Lausanne). .

Abstract

Background: A possible relationship between oral lichen planus (OLP) and thyroid disease has received attention in recent years.

Objective: This study aimed to evaluate the correlation between OLP and thyroid diseases in Chinese ethnic patients.

Methods: 192 OLP patients, 123 patients with oral lichenoid lesions (OLLs), and 162 controls were recruited in this case-control study. All participants received screening for thyroid function and underwent ultrasound. Sex and age of the patients in the three groups were matched. The prevalence of thyroid diseases in the subjects was analyzed. Using logistic regression, the odds ratio (OR) with 95% confidence intervals was appraised for associations between OLP, OLL, and different types of thyroid diseases [Hashimoto's thyroiditis (HT), hypothyroidism, and thyroid nodule].

Results: The prevalence of thyroid diseases in the OLP group (72.4%) and OLL group (68.3%) was higher than the control group (49.4%) with statistical significance. The OR of HT was 3.16 (1.87-5.33) for OLP, 2.09 (1.18-3.70) for OLL, while the OR of thyroid nodule was 2.31 (1.30-4.09) for OLP.

Conclusion: Our study suggested a close relationship between OLP/OLL and HT and thyroid nodule in a Chinese population. The possible mechanism behind this association warrants further investigation.

Keywords: Hashimoto’s thyroiditis; hypothyroidism; molecular mimicry; oral lichen planus; oral lichenoid lesion; thyroid nodule.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Srinivas K, Aravinda K, Ratnakar P, Nigam N, Gupta S. Oral lichen planus – review on etiopathogenesis. Natl J Maxillofac Surg (2011) 2:15–6.10.4103/0975-5950.85847 - DOI - PMC - PubMed
    1. Eisen D, Carrozzo M, Bagan SJ, Thongprasom K. Number V oral lichen planus: clinical features and management. Oral Dis (2005) 11:338–49.10.1111/j.1601-0825.2005.01142.x - DOI - PubMed
    1. Warnakulasuriya S, Johnson NW, van der Waal I. Nomenclature and classification of potentially malignant disorders of the oral mucosa. J Oral Pathol Med (2007) 36:575–80.10.1111/j.1600-0714.2007.00582.x - DOI - PubMed
    1. Fitzpatrick SG, Hirsch SA, Gordon SC. The malignant transformation of oral lichen planus and oral lichenoid lesions: a systematic review. J Am Dent Assoc (2014) 145:45–56.10.14219/jada.2013.10 - DOI - PubMed
    1. Scully C, Beyli M, Ferreiro MC, Ficarra G, Gill Y, Griffiths M, et al. Update on oral lichen planus: etiopathogenesis and management. Crit Rev Oral Biol Med (1998) 9:86–122.10.1177/10454411980090010501 - DOI - PubMed

LinkOut - more resources