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. 2018 Oct;44(10):1735-1737.
doi: 10.1007/s00134-018-5289-3. Epub 2018 Jul 2.

The Boldt scandal still in need of action: the example of colloids 10 years after initial suspicion of fraud

Christian J Wiedermann  1 , Michael Joannidis  2
Affiliations

The Boldt scandal still in need of action: the example of colloids 10 years after initial suspicion of fraud

Christian J Wiedermann et al. Intensive Care Med. 2018 Oct.

Erratum in

No abstract available

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Conflict of interest statement

CJW has received lecture fees and/or travel cost reimbursements from the Plasma Protein Therapeutics Association, Kedrion, CSL Behring, Grifols and Baxter, and remuneration for consulting from CSL Behring, Grifols, and Daiichi Sankyo. MJ has received fees for lectures and/or consulting from Baxter, CSL Behring, Fresenius and Astute Medical, and research grand support from Fresenius.

Figures

Fig. 1
Fig. 1
Flowchart of the fate of 44 publications of randomized clinical studies on volume therapy with colloids with Boldt as an author. *Additional search terms were “hydroxyethyl” or “albumin” in title/abstract and search performed on June 7, 2018. ‡Studies at the University of Giessen and Ludwigshafen were between 1985 and 1998 (mean annual RCT rate, 1.93) and from 1999 to 2010 (mean annual RCT rate, 1.42), respectively. †Lead author = first, senior, or corresponding author
See this image and copyright information in PMC

References

    1. Boldt J, Suttner S, Brosch C, et al. Cardiopulmonary bypass priming using a high dose of a balanced hydroxyethyl starch versus an albumin-based priming strategy. Anesth Analg. 2009;109:1752–1762. doi: 10.1213/ane.0b013e3181b5a24b. - DOI - PubMed
    1. Klinikum Ludwigshafen (2010) Untersuchungsbericht der Kommission für die Pressekonferenz am 29. November 2010. https://www.klilu.de/content/veranstaltungen___presse/pressearchiv/2010/.... Accessed 9 Jun 2018
    1. Shafer SL. Notice of retraction. Anesth Analg. 2010;111:1567. doi: 10.1213/ane.0b013e3182040b99. - DOI - PubMed
    1. Rasmussen LS, Yentis SM, Van Aken H et al (2011) Editors-in-chief statement regarding published clinical trials conducted without IRB approval by Joachim Boldt. Minerva Anesthesiol 77:562–563 - PubMed
    1. Boldt J, Brosch C, Ducke M, et al. Influence of volume therapy with a modern hydroxyethylstarch preparation on kidney function in cardiac surgery patients with compromised renal function: a comparison with human albumin. Crit Care Med. 2007;35:2740–2746. doi: 10.1097/01.CCM.0000288101.02556.DE. - DOI - PubMed

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