Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018 Jun;50(2):101-109.
doi: 10.3947/ic.2018.50.2.101.

Review of Disinfection and Sterilization - Back to the Basics

Affiliations
Review

Review of Disinfection and Sterilization - Back to the Basics

Jin Hong Yoo. Infect Chemother. 2018 Jun.

Abstract

In-depth knowledge of disinfection and sterilization is a key component of infection control. Sterilization completely removes a spore, whereas disinfection cannot. Disinfectants are classified as oxidants and non-oxidants. The decision regarding which method to apply is based on Spaulding's classification. In this article, disinfection and sterilization are thoroughly reviewed, and extensive information from basic to practical points is discussed.

Keywords: Disinfection; Infection control; Sterilization.

PubMed Disclaimer

Conflict of interest statement

No conflicts of interest.

Figures

Figure 1
Figure 1
Structure of oxidizing agents. (A) sodium hypochlorite (B) povidone-iodine (C) hydrogen peroxide (D) peracetic acid.
Figure 2
Figure 2
Structure of non-oxidizing agents (coagulants). (A) ethanol (B) chlorhexidine (C) quaternary ammonium compound (D) glutaraldehyde (E) ortho-phthalaldehyde (F) ethylene oxide.

Similar articles

Cited by

References

    1. Yoo JH. Principle and perspective of healthcare-associated infection control. J Korean Med Assoc. 2018;61:5–12.
    1. Stokes HW, Gillings MR. Gene flow, mobile genetic elements and the recruitment of antibiotic resistance genes into Gram-negative pathogens. FEMS Microbiol Rev. 2011;35:790–819. - PubMed
    1. Centers for Disease Control and Prevention (CDC) Disinfection and sterilization. [Accessed 15 April 2018]. Available at: https://www.cdc.gov/infectioncontrol/guidelines/disinfection/index.html.
    1. Rutala WA, Weber DJ. Disinfection, sterilization, and antisepsis: An overview. Am J Infect Control. 2016;44(Suppl):e1–e6. - PubMed
    1. McDonnell G, Russell AD. Antiseptics and disinfectants: activity, action, and resistance. Clin Microbiol Rev. 1999;12:147–179. - PMC - PubMed