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. 2018 Jul 3;18(1):280.
doi: 10.1186/s12884-018-1914-y.

Measurement of area difference ratio of Photoplethysmographic pulse wave in patients with pre-eclampsia

Ying Feng  1 , Dan Drzymalski  2 , Baihui Zhao  3 , Xuan Wang  4 , Xinzhong Chen  5
Affiliations

Measurement of area difference ratio of Photoplethysmographic pulse wave in patients with pre-eclampsia

Ying Feng et al. BMC Pregnancy Childbirth. .

Abstract

Background: Preeclampsia (PE) is associated with an increase in maternal arterial stiffness, which may be reflected by photoplethysmography (PPG) of the pulse wave. The aim of this study was to investigate area difference ratio (ADR), a novel parameter derived from PPG, in women with and without preeclampsia.

Methods: Patients with and without preeclampsia in the third trimester were enrolled. All patients had photoplethysmography of the pulse wave assessed. ADR was compared between the two groups.

Results: Seventy-two patients in the third trimester of gestation, of which 36 had preeclampsia and 36 did not, were enrolled. The ADR was lower in the preeclampsia group vs. the non-preeclampsia group (0.725 [IQR 0.681-0.779] vs. 0.752 [IQR 0.717-0.910], P < 0.01).

Conclusions: Measuring the ADR through analyzing PPG of the pulse wave may be a useful diagnostic tool in patients with preeclampsia.

Keywords: Area difference ratio; Hypertension; Photoplethysmography; Preeclampsia.

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Conflict of interest statement

Ethics approval and consent to participate

The study protocol was approved by the local Research Ethics Committee of the Women’s Hospital, School of Medicine, Zhejiang University and written informed consent was obtained from all patients who participated in the study.

Consent for publication

Not applicable.

Competing interests

The authors declare that they have no competing interests.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
A representive beat of pulse photoplethysmographic waveform. Baseline is corrected to 0. Point A, P and B are the onset, peak and end position of pulse, respectively. Point O is the vertical projection of point P on the baseline. PPG signal (−) is shown with PPG magnitude in arbitrary units (au)
Fig. 2
Fig. 2
Box and whisker plots comparing the ADR in the PE group during pregnancy (left), and postpartum (right). Boxes represent IQR, where the line represents the median. Whiskers at top and bottom of the box represent the highest and lowest values
See this image and copyright information in PMC

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