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Review
. 2019 Mar;143(3):844-851.
doi: 10.1016/j.jaci.2018.05.021. Epub 2018 Jun 30.

Novel vaccines: Technology and development

Sarita U Patil  1 , Wayne G Shreffler  2
Affiliations
Review

Novel vaccines: Technology and development

Sarita U Patil et al. J Allergy Clin Immunol. 2019 Mar.

Abstract

The development and widespread use of vaccines, which are defined by the World Health Organization as "biological preparations that improve immunity to a particular disease," represents one of the most significant strides in medicine. Vaccination was first applied to reduce mortality and morbidity from infectious diseases. The World Health Organization estimates that vaccines prevent 2 to 3 million human deaths annually, and these numbers would increase by at least 6 million if all children received the recommended vaccination schedule. However, the origins of allergen immunotherapy share the same intellectual paradigm, and subsequent innovations in vaccine technology have been applied beyond the prevention of infection, including in the treatment of cancer and allergic diseases. This review will focus on how new and more rational approaches to vaccine development use novel biotechnology, target new mechanisms, and shape the immune system response, with an emphasis on discoveries that have direct translational relevance to the treatment of allergic diseases.

Keywords: Vaccines; antibodies; immunotherapy; sequencing.

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Conflict of interest statement

Declaration of Conflict of Interest

This work did not receive any specific grant from funding agencies in the public, commercial, or not for profit sectors.

Figures

Figure 1:
Figure 1:. Translational mechanisms for future innovations in immunotherapy for allergies
Novel approaches for allergen specific immunotherapy include bispecific molecules targeting antigen-specific B cells or allergen-specific Th2 cells, DC-targeting vaccines, sequential immunization strategies to elicit enhanced blocking antibodies, and passive immunization with inhibitory IgG antibodies
See this image and copyright information in PMC

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