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Observational Study
. 2018 Jun 5:2018:6929732.
doi: 10.1155/2018/6929732. eCollection 2018.

Risk Factors for the Progression of Mild Cognitive Impairment in Different Types of Neurodegenerative Disorders

Pei-Hao Chen  1   2   3 , Shih-Jung Cheng  1   2   4 , Hui-Chi Lin  1 , Chuo-Yu Lee  1   2   5 , Chih-Ho Chou  6   7
Affiliations
Observational Study

Risk Factors for the Progression of Mild Cognitive Impairment in Different Types of Neurodegenerative Disorders

Pei-Hao Chen et al. Behav Neurol. .

Abstract

Objective: Mild cognitive impairment (MCI) is a transitional state between normal aging and early dementia. It has a heterogeneous etiology and clinical course. This study aimed to examine the factors associated with the progression of MCI in different types of dementia disorders.

Method: A retrospective, longitudinal, observational study of outpatients with MCI was conducted at a medical center in northern Taiwan. Patient medical records were reviewed, and risk factors were analyzed by multivariate analysis.

Results: Among 279 patients with MCI, 163 (58.4%), 68 (24.4%), and 48 (17.2%) were diagnosed with Alzheimer's disease, vascular cognitive impairment, and Lewy body diseases, respectively. During the observation period, 37.2% of patients progressed to dementia. Older age and a higher Clinical Dementia Rating Scale-Sum of Boxes were associated with the risk of progression. Hyperlipidemia was associated with a decreased risk. Converters were more likely to receive an antidementia prescription.

Conclusion: Our study suggests the importance of comprehensive clinical profiling, risk factor assessment, and detailed drug history evaluations in improving our understanding and management of dementia subtypes.

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Figures

Figure 1
Figure 1
Flow diagram showing the patient exclusion criteria.
Figure 2
Figure 2
Proportions of conversion to dementia in patients with different clinical diagnoses. AD: Alzheimer's disease; VaD: vascular dementia; LBD: Lewy body diseases.
See this image and copyright information in PMC

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References

    1. Petersen R. C., Lopez O., Armstrong M. J., et al. Practice guideline update summary: mild cognitive impairment: report of the guideline development, dissemination, and implementation subcommittee of the American Academy of Neurology. Neurology. 2018;90(3):126–135. doi: 10.1212/WNL.0000000000004826. - DOI - PMC - PubMed
    1. Baumgart M., Snyder H. M., Carrillo M. C., Fazio S., Kim H., Johns H. Summary of the evidence on modifiable risk factors for cognitive decline and dementia: a population-based perspective. Alzheimer’s & Dementia. 2015;11(6):718–726. doi: 10.1016/j.jalz.2015.05.016. - DOI - PubMed
    1. Reijmer Y. D., Berg E., Dekker J. M., et al. Development of vascular risk factors over 15 years in relation to cognition: the Hoorn study. Journal of the American Geriatrics Society. 2012;60(8):1426–1433. doi: 10.1111/j.1532-5415.2012.04081.x. - DOI - PubMed
    1. Hu G.-C., Chen Y.-M. Post-stroke dementia: epidemiology, mechanisms and management. International Journal of Gerontology. 2017;11(4):210–214. doi: 10.1016/j.ijge.2017.07.004. - DOI
    1. Dugger B. N., Malek-Ahmadi M., Monsell S. E., et al. A cross-sectional analysis of late-life cardiovascular factors and their relation to clinically defined neurodegenerative diseases. Alzheimer Disease & Associated Disorders. 2016;30(3):223–229. doi: 10.1097/WAD.0000000000000138. - DOI - PMC - PubMed

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