Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Oct;46(5):701-704.
doi: 10.1007/s15010-018-1170-0. Epub 2018 Jul 3.

A nationwide passive surveillance on fungal infections shows a low burden of azole resistance in molds and yeasts in Tyrol, Austria

Cornelia Lass-Flörl  1 , Astrid Mayr  2 , Maria Aigner  2 , Michaela Lackner  2 , Dorothea Orth-Höller  2
Affiliations

A nationwide passive surveillance on fungal infections shows a low burden of azole resistance in molds and yeasts in Tyrol, Austria

Cornelia Lass-Flörl et al. Infection. 2018 Oct.

Abstract

Purpose: To determine the burden of antifungal resistance in fungi over the last 10 years.

Methods: Performance of a semi-nationwide surveillance on antifungal resistance.

Results: We observed a low frequency of azole resistance in Aspergillus fumigatus, a moderate increase of echinocandin resistance in yeasts, and a stable amphotericin B activity in yeasts and molds. Posaconazole resistance in Aspergillus terreus occurred in a few isolates.

Conclusion: The burden of resistance in fungi seems to be low in Tyrol, Austria.

Keywords: Antifungals; Fungal infections; Fungal surveillance; Resistance.

PubMed Disclaimer

Conflict of interest statement

Cornelia Lass-Flörl received speakers honoraria from Gilead, Merck/MSD and Pfizer, reseach grants from Gilead and Pfizer, and is a consultant to Pfizer, Gilead and Basilea. Other authors declare that they have no competing interests.

References

    1. Sun KS, Tsau CF, Chen SC, Huang WC. Clinical outcome and prognostic factors associated with invasive pulmonary aspergillosis: an 11-year follow-up report from Taiwan. PLoS One. 2017;12:e0186422. doi: 10.1371/journal.pone.0186422. - DOI - PMC - PubMed
    1. Lass-Flörl C, Aigner M, Nachbaur D, Eschertzhuber S, Bucher B, Geltner C, et al. Diagnosing filamentous fungal infections in immunocompromised patients applying computed tomography-guided percutaneous lung biopsies: a 12-year experience. Infection. 2017;45:867–875. doi: 10.1007/s15010-017-1072-6. - DOI - PMC - PubMed
    1. Tacconelli E, Sifakis F, Harbarth S, Schrijver R, Van Mourik M, Voss A. Surveillance for control of antimicrobial resistance. Lancet Infect Dis. 2018;18:399–106. doi: 10.1016/S1473-3099(17)30753-3. - DOI - PubMed
    1. Chowdhary A, Sharma C, Meis J. Azole-resistant aspergillosis: epidemiology, molecular mechanisms, and treatment. J Infect Dis. 2017;216:436–444. doi: 10.1093/infdis/jix210. - DOI - PubMed
    1. Arendrup MC, Cuenca-Estrella M, Lass-Flörl C, Hope W, EUCAST-AFST EUCAST technical note on the EUCAST definitive document EDef 7.2: method for the determination of broth dilution minimum inhibitory concentrations of antifungal agents for yeasts EDef 7.2 (EUCAST-AFST) Clin Microbiol Infect. 2012;18:E246–E247. doi: 10.1111/j.1469-0691.2012.03880.x. - DOI - PubMed

LinkOut - more resources