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. 2018 Jul;111(1):39-47.
doi: 10.5935/abc.20180109. Epub 2018 Jul 2.

Adropin and Irisin in Patients with Cardiac Cachexia

[Article in English, Portuguese]
Ali Kemal Kalkan  1 , Huseyin Altug Cakmak  2 , Mehmet Erturk  1 , Kübra Erol Kalkan  3 , Fatih Uzun  1 , Omer Tasbulak  1 , Vesile Ornek Diker  4 , Suleyman Aydin  5 , Ahmet Celik  6
Affiliations

Adropin and Irisin in Patients with Cardiac Cachexia

[Article in English, Portuguese]
Ali Kemal Kalkan et al. Arq Bras Cardiol. 2018 Jul.

Abstract

Background: Cardiac cachexia is an important predictive factor of the reduction in survival of patients with heart failure with reduced ejection fraction.

Objectives: The aims of the present study were to evaluate adropin and irisin levels in cachectic and non-cachectic subjects and the relationships between the levels of these proteins and clinical and laboratory parameters in patients with HFrEF.

Methods: The clinical records of patients who were admitted to the cardiology outpatient clinic for heart failure with reduced ejection fraction were screened. Cachectic patients were identified and assigned to the study group (n = 44, mean age, 65.4 ± 11.2 y; 61.4% men). Heart failure with reduced ejection fraction patients without weight loss were enrolled as the control group (n = 42, mean age, 61.0 ± 16.5 y; 64.3% men). The serum adropin and irisin levels of all patients were measured. A p-value < 0.05 was considered significant.

Results: Serum adropin and irisin levels were significantly higher in the cachexia group than in the controls (Adropin (ng/L); 286.1 (231.3-404.0) vs 213.7 (203.1-251.3); p < 0.001, Irisin (µg/mL); 2.6 (2.2-4.4) vs 2.1 (1.8-2.4); p = 0.001). Serum adropin and irisin levels were positively correlated with brain natriuretic peptide (BNP) levels and New York Heart Association (NYHA) class and negatively correlated with body mass index (BMI) and serum albumin levels (all p values: < 0.001). In a multivariate analysis, adropin was the only independent predictor of cachexia in the heart failure with reduced ejection fraction patients (OR: 1.021; 95% CI: 1.004-1.038; p = 0.017).

Conclusions: The results suggest that adropin and irisin may be novel markers of cardiac cachexia in heart failure with reduced ejection fraction patients. Adropin and irisin are related with the severity of heart failure.

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Conflict of interest statement

Potential Conflict of Interest

No potential conflict of interest relevant to this article was reported.

Figures

Figure 1
Figure 1
Body weight difference between cachectic and non-cachectic groups.
Figure 2
Figure 2
Receiver-operating characteristic curve for discriminative value of serum adropin, irisin and BNP levels in systolic heart failure with reduced ejection fraction patients with or without cachexia.
See this image and copyright information in PMC

Comment in

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