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. 2018 Jul 4;18(1):138.
doi: 10.1186/s12872-018-0873-6.

Association between increased serum alkaline phosphatase and the coronary slow flow phenomenon

Yong Wang  1 , Mou-Jie Liu  2 , Hui-Min Yang  2 , Chun-Yan Ma  3 , Peng-Yu Jia  2 , Da-Lin Jia  4 , Ai-Jie Hou  5
Affiliations

Association between increased serum alkaline phosphatase and the coronary slow flow phenomenon

Yong Wang et al. BMC Cardiovasc Disord. .

Abstract

Background: Despite marked advances in our understanding of the pathophysiology of the coronary slow flow phenomenon (CSFP), the exact mechanism remains unclear. Previous studies have suggested that CSFP might be associated with generalized atherosclerosis, endothelial dysfunction, and low-grade chronic inflammation. High serum alkaline phosphatase (ALP) levels are associated with vascular calcification, atherosclerotic disease, and an increased risk of cardiovascular events. However, the relationship between ALP and CSFP is unclear.

Methods: We investigated 64 patients with angiographically proven CSFP and 50 with normal coronary flow. Serum ALP levels were measured in all studied individuals.

Results: Serum ALP levels in patients with CSFP were significantly higher than those in the control group (70.5 ± 17.1 vs. 61.9 ± 16.1 U/L, P = 0.007). A positive association was observed (r = 0.42, P = 0.032) between serum ALP levels and the mean thrombolysis in myocardial infarction frame count (mTFC). Regression analysis showed a high serum ALP level was the only independent predictor of the mTFC (β = 0.309, P < 0.001). Moreover, our study showed that a serum ALP level > 67.5 U/L was a predictor of CSFP (sensitivity = 83.3%, specificity = 84.1%).

Conclusions: Patients with CSFP show high serum ALP levels, which may be associated with the pathogenesis of CSFP. A high serum ALP level is a predictor of CSFP. Future studies are needed to clarify the role of ALP in patients with CSFP.

Keywords: Coronary angiography; Coronary slow flow phenomenon; Serum alkaline phosphatase; TIMI flame count.

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Conflict of interest statement

Ethics approval and consent to participate

The study had already been approved by Ethics Committee of the First Hospital of China Medical University and all subjects provided their informed, written consent before participation.

Competing interests

The authors declare that they have no competing interests.

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Figures

Fig. 1
Fig. 1
Correlation between the number of coronary arteries involved in CSFP and serum ALP level
Fig. 2
Fig. 2
Correlation between mean TFC and serum ALP level
Fig. 3
Fig. 3
The receiver-operating characteristic(ROC) curve for the discrimination of patients with CSFP at least in one of the coronary arteries from patients with the normar controls
See this image and copyright information in PMC

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