Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Oct;45(5):911-916.
doi: 10.1007/s11033-018-4237-1. Epub 2018 Jul 4.

The association between cardiovascular disease gene mutations and recurrent pregnancy loss in the Lebanese population

Hanadi El Achi  1 , Johnny Awwad  2 , Sarah Abou Daya  1 , Sahar Halabi  1 , Sandra Damianos  1 , Rami Mahfouz  3
Affiliations

The association between cardiovascular disease gene mutations and recurrent pregnancy loss in the Lebanese population

Hanadi El Achi et al. Mol Biol Rep. 2018 Oct.

Abstract

Recurrent pregnancy loss (RPL) is a problem affecting up to 5% of women of childbearing age due to many factors. Studies have shown that RPL and cardiovascular disease (CVD) may have shared risk factors. We compared the prevalence of 12 cardiovascular disease related gene mutations in patients with a history of RPL to normal controls in a major tertiary care center in Lebanon. The CVD StripAssay (ViennaLab, Austria) was used to analyze the CVD genes on 70 women with RPL history as part of the initial routine workup for recurrent miscarriage at the American University of Beirut Medical Center. The obtained results were compared with data of controls from the Lebanese population using Fisher's exact test and Chi square analysis. Two genes of the CVD panel demonstrated a strong relationship with RPL, including, MTHFR (C677T homozygosity, A1298C homozygosity, and compound heterozygosity for C677T and A1298C) and Factor II (heterozygosity for G20210A). Moreover, a protective role of positive APO-E3 isoform was observed. This study is the first in the Lebanese population in associating RPL with a large panel of CVD related genes.

Keywords: Cardiovascular; Genes; Loss; Pregnancy.

PubMed Disclaimer

References

    1. Am J Reprod Immunol. 2006 Oct;56(4):230-6 - PubMed
    1. Thromb Haemost. 1998 Dec;80(6):1029-30 - PubMed
    1. Fertil Steril. 2008 Nov;90(5 Suppl):S21-9 - PubMed
    1. Genet Test Mol Biomarkers. 2012 Apr;16(4):279-86 - PubMed
    1. Clin Chem. 2009 Mar;55(3):407-19 - PubMed

LinkOut - more resources