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. 2018 Dec;20(12):2733-2739.
doi: 10.1111/dom.13452. Epub 2018 Jul 27.

Effects of the interaction between glycated haemoglobin genetic risk score and postpartum weight reduction on glycaemic changes: A gene-weight interaction analysis

Liyuan Han  1   2 , Donghui Duan  1   2   3 , Shuang Zhang  4 , Weiqin Li  4 , Leishen Wang  4 , Huikun Liu  4 , Junhong Leng  4 , Nan Li  4 , Xiaoyun Shang  5 , Gang Hu  6 , Lu Qi  2   7   8   9
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Effects of the interaction between glycated haemoglobin genetic risk score and postpartum weight reduction on glycaemic changes: A gene-weight interaction analysis

Liyuan Han et al. Diabetes Obes Metab. 2018 Dec.

Abstract

Aim: To investigate the effects of the interaction between glycated haemoglobin (HbA1c) genetic risk score and weight changes during and after pregnancy (postpartum weight reduction and gestational weight gain) on long-term glycaemic changes in the largest cohort of women with a history of gestational diabetes mellitus (GDM).

Methods: This was a retrospective cohort using the baseline data from the Tianjin Gestational Diabetes Mellitus Prevention Programme. A genetic risk score was established by combining 10 HbA1c-related single-nucleotide polymorphisms, which were identified by genome-wide association studies. General linear regression models were applied to evaluate the effect of interaction between HbA1c genetic risk score and weight changes during and after pregnancy (postpartum weight reduction and gestational weight gain) on glycaemic changes.

Results: 'A total of 1156 women with a history of GDM were included in this respective cohort study. Statistical differences in pre-pregnancy weight, pre-delivery weight and postpartum weight were evidenced across different groups of postpartum weight reduction. After adjusting for covariates, statistical significance for changes in HbA1c level was only observed in the postpartum weight reduction <5 kg/y group (P = 0.002), and a significant effect of interaction between HbA1c genetic risk score and postpartum weight reduction on long-term changes in HbA1c was evidenced (P interaction = 0.01). In women with postpartum weight reduction ≥8 kg/y, those with a lower HbA1c genetic risk score had a greater decrease in HbA1c level.

Conclusions: HbA1c genetic risk score interacts with postpartum weight reduction to affect long-term changes in HbA1c levels among women with a history of GDM.

Keywords: genetic risk score; gestational diabetes mellitus; glycaemic changes; postpartum weight reduction.

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Conflict of interest statement

Conflict of interest

The authors have no conflicts of interest to disclose

Figures

Figure 1.
Figure 1.
Changes in glycemic traits according to weight reduction and HbA1c genetic risk score.
Figure 2.
Figure 2.
Predicted differences in glycemic traits stratified by HbA1c genetic risk score.
See this image and copyright information in PMC

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References

    1. Kew S, Ye C, Hanley AJ, et al. Cardiometabolic implications of postpartum weight changes in the first year after delivery. Diabetes care. 2014;37: 1998–2006. - PubMed
    1. Saldana TM, Siega-Riz AM, Adair LS,Suchindran C. The relationship between pregnancy weight gain and glucose tolerance status among black and white women in central North Carolina. Am J Obstet Gynecol. 2006;195: 1629–1635. - PubMed
    1. Catalano PM,Shankar K. Obesity and pregnancy: mechanisms of short term and long term adverse consequences for mother and child. Bmj. 2017;356: j1. - PMC - PubMed
    1. Fraser A, Tilling K, Macdonald-Wallis C, et al. Associations of gestational weight gain with maternal body mass index, waist circumference, and blood pressure measured 16 y after pregnancy: the Avon Longitudinal Study of Parents and Children (ALSPAC). The American journal of clinical nutrition. 2011;93: 1285–1292. - PMC - PubMed
    1. Willett WC, Manson JE, Stampfer MJ, et al. Weight, weight change, and coronary heart disease in women. Risk within the ‘normal’ weight range. Jama. 1995;273: 461–465. - PubMed

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