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. 2018 Jun;8(6):e00955.
doi: 10.1002/brb3.955. Epub 2018 Apr 21.

Correlation between cortical lesions and cognitive impairment in multiple sclerosis

Erica Curti  1 , Stefania Graziuso  2 , Elena Tsantes  1 , Girolamo Crisi  2 , Franco Granella  1
Affiliations

Correlation between cortical lesions and cognitive impairment in multiple sclerosis

Erica Curti et al. Brain Behav. 2018 Jun.

Abstract

Objectives: Gray matter (GM) damage is well known as a fundamental aspect of multiple sclerosis (MS). Above all, cortical lesions (CLs) burden, detectable at MRI with double inversion recovery (DIR) sequences, has been demonstrated to correlate with cognitive impairment (CI). The aim of this study was to investigate the role of CLs number in predicting CI in a cohort of patients with MS in a clinical practice setting.

Materials and methods: Thirty consecutive patients with MS presenting CLs (CL+) at high-field (3.0 T) MRI 3D-DIR sequences and an even group of MS patients without CLs (CL-) as a control, were investigated with the Rao Brief Repeatable Battery of Neuropsychological Tests (BRB), Version A. Total and lobar CLs number were computed in CL+ patients.

Results: Among the sixty patients with MS enrolled, forty-seven (78.3%) had a relapsing-remitting course, while thirteen (21.7%) a progressive one, eleven secondary progressive, and two primary progressive. Compared to CL-, CL+ patients had a greater proportion of progressive forms (p = .03). The most affected region was the frontal lobe (73.3% of patients), followed by temporal and parietal ones (both 60.0%). Multivariate (logistic regression) analysis revealed a significant correlation between total CLs number and the presence of mild cognitive impairment defined as pathologic score in at least one BRB test (p = .04); it was also correlated with deficit at PASAT 3 (p = .05) and Stroop Test (p = .02).

Conclusions: We confirmed CLs number, evaluated with a technique quite commonly available in clinical practice, as a predictive factor of CI in patients with MS, in order to improve the diagnosis and management of CI and monitor potential neuroprotective effects of therapies.

Keywords: cognitive impairment; cortical lesions; double inversion recovery; multiple sclerosis.

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Figures

Figure 1
Figure 1
(a‐d) Examples of cortical lesions (white arrows) detected with 3D‐DIR in axial (a and d), coronal (b), and sagittal (c) scans in our population
See this image and copyright information in PMC

References

    1. Amato, M. P. , Portaccio, E. , Goretti, B. , Zipoli, V. , Ricchiuti, L. , De Caro, M. F. , … Trojano, M. (2006). The Rao's Brief Repeatable Battery and Stroop Test: Normative values with age, education and gender corrections in an Italian population. Multiple Sclerosis, 12, 787–793. https://doi.org/10.1177/1352458506070933 - DOI - PubMed
    1. Amato, M. P. , Zipoli, V. , & Portaccio, E. (2006). Multiple sclerosis‐related cognitive changes: A review of cross‐sectional and longitudinal studies. Journal of the Neurological Sciences, 245, 41–46. https://doi.org/10.1016/j.jns.2005.08.019 - DOI - PubMed
    1. Calabrese, M. , Agosta, F. , Rinaldi, F. , Mattisi, I. , Grossi, P. , Favaretto, A. , … Filippi, M. (2009). Cortical lesions and atrophy associated with cognitive impairment in relapsing‐ remitting multiple sclerosis. Archives of Neurology, 66, 1144–1150. - PubMed
    1. Calabrese, M. , De Stefano, N. , Atzori, M. , Bernardi, V. , Mattisi, I. , Barachino, L. , … Gallo, P. (2007). Detection of cortical inflammatory lesions by double inversion recovery magnetic resonance imaging in patients with multiple sclerosis. Archives of Neurology, 64, 1416–1422. https://doi.org/10.1001/archneur.64.10.1416 - DOI - PubMed
    1. Calabrese, M. , Favaretto, A. , Martini, V. , & Gallo, P. (2013). Grey matter lesions in MS: From histology to clinical implications. Prion, 7, 20–27. https://doi.org/10.4161/pri.22580 - DOI - PMC - PubMed

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