Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Oct;22(4):320-325.
doi: 10.1097/LGT.0000000000000416.

Human Papillomavirus Correlates With Histologic Anal High-Grade Squamous Intraepithelial Lesions in Hispanics With HIV

Diana T Medina-Laabes  1   2 , Erick L Suarez-Perez  1 , Humberto M Guiot  3   4 , Cristina Muñoz  2 , Vivian Colón-López  2   5 , Maribel Tirado-Gómez  2   3 , Ana Patricia Ortiz  1   2
Affiliations

Human Papillomavirus Correlates With Histologic Anal High-Grade Squamous Intraepithelial Lesions in Hispanics With HIV

Diana T Medina-Laabes et al. J Low Genit Tract Dis. 2018 Oct.

Abstract

Objective: To estimate the magnitude of association between anal infection with high-risk human papilloma virus (HR-HPV) types and severity of biopsy-confirmed histopathological anal squamous intraepithelial lesions (SILs) among a clinic-based sample of HIV-infected adults in Puerto Rico.

Methods: This cross-sectional study analyzed data from medical records of adult patients who visited a specialized anal neoplasia clinic from June 2015 to December 2017 (n = 239); sociodemographics, behavioral risk factors, medical history, clinical data, and pathology reports were collected. The magnitude of association between anal HR-HPV and severity of anal SIL, adjusted for potential confounders, was assessed using a multinomial logistic model.

Results: A 78.7% of patients had anal HR-HPV infection, 43.9% had histopathological low-grade SIL (LSIL), and 37.7% had histopathological high-grade SIL (HSIL). The prevalence of anal HR-HPV infection was 63.6% among patients with no anal SIL, 70.5% for those with LSIL and 95.6% for those with HSIL. After adjusting for different predictors, patients with anal HR-HPV infection were more likely to have HSIL (odds ratio, 11.0; 95% confidence interval, 3.2-37.2) than those without anal HR-HPV infection, whereas no significant excess was observed for LSIL (odds ratio, 1.4; 95% confidence interval, 0.6-3.1).

Conclusions: This study showed a strong association between anal HR-HPV infection and HSIL. Likewise, a high prevalence of anal HR-HPV infection and presence of anal SIL was observed among HIV-infected individuals. Our result highlights the importance of screening for anal HR-HPV infection and anal SIL and optimizing strategies for HPV vaccination in HIV-infected individuals.

PubMed Disclaimer

Conflict of interest statement

Published conflict of interest statement: The authors do not have any significant conflict to disclose.

Conflict of interest stament: The authors have declared they have no conflicts of interest.

Figures

Figure 1:
Figure 1:
Severity of histopathological anal SIL overall and among sexual risk groups in a clinic-based sample of HIV-infected Hispanic adults (n = 239); p > .05.
Figure 2.
Figure 2.
Prevalence of anal HR-HPV infection overall and according to severity of histopathological anal SIL in a clinic-based sample of HIV-infected Hispanic adults (n = 239). †Other HR-HPV includes HPV types 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, and 68. *p < .05.
See this image and copyright information in PMC

References

    1. Islami F, Ferlay J, Lortet-Tieulent J, et al. International trends in anal cancer incidence rates. International Journal of Epidemiology 2016;46:924–938. - PubMed
    1. Palefsky J Human papillomavirus infection and its role in the pathogenesis of anal cancer. In Seminars in Colon and Rectal Surgery 2017;28:57–62.
    1. de Martel C, Plummer M, Vignat J, Franceschi S. Worldwide burden of cancer attributable to HPV by site, country and HPV type. International Journal of Cancer 2017;141:664–670. - PMC - PubMed
    1. Colón-López V, Shiels MS, Machin M, et al. Anal cancer risk among people with HIV infection in the United States. Journal of Clinical Oncology 2017;36:68–75. - PMC - PubMed
    1. Lin C, Franceschi S, Clifford GM. Human papillomavirus types from infection to cancer in the anus, according to sex and HIV status: a systematic review and meta-analysis. The Lancet Infectious Diseases 2017; November 17 pii: S1473–3099(17)30653–9. doi: 10.1016/S1473-3099(17)30653-9. [Epub ahead of print] - DOI - PMC - PubMed

MeSH terms