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Review
. 2018 Sep 25;33(3):247-264.
doi: 10.1515/reveh-2017-0033.

Air pollution exposure during pregnancy and spontaneous abortion and stillbirth

Alexandra Grippo  1 , Jun Zhang  2 , Li Chu  2 , Yanjun Guo  3 , Lihua Qiao  4 , Jun Zhang  4 , Ajay A Myneni  1 , Lina Mu  1
Affiliations
Review

Air pollution exposure during pregnancy and spontaneous abortion and stillbirth

Alexandra Grippo et al. Rev Environ Health. .

Abstract

The developing fetus is particularly susceptible to environmental pollutants, and evidence has shown adverse effects of air pollutants on pregnancy and birth outcomes. Pregnancy loss, including spontaneous abortion (miscarriage) and stillbirth, is the most severe adverse pregnancy outcome. This review focuses on air pollution exposure during pregnancy in relation to spontaneous abortion and stillbirth. A total of 43 studies are included in this review, including 35 human studies and eight animal studies. Overall, these studies suggest that exposure to air pollutants such as particulate matter (PM), carbon monoxide (CO) and cooking smoke may be associated with higher risk for stillbirth and spontaneous abortion. PM10 exposure during an entire pregnancy was associated with increased risk of spontaneous abortion, and exposure to PM2.5 and PM10 in the third trimester might increase the risk of stillbirth. CO exposure during the first trimester of pregnancy was associated with an increased risk of spontaneous abortion and exposure during the third trimester was associated with an increased risk of stillbirth. Cooking smoke was found to increase the risk of stillbirths, and the evidence was consistent. Insufficient and conflicting evidence was found for various other pollutants, such as NO2 and SO2. Studies did not show clear evidence for associations between pregnancy loss and others pollutants such as heavy metals, organochlorine compounds, PAH and total dust count. Further research is warranted to better understand the relationship between air pollution exposure and pregnancy loss.

Keywords: cooking smoke; fetal death; intrauterine mortality; miscarriage; particulate matter.

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Conflict of interest statement

Conflict of interest: Authors state no conflict of interest.

References

    1. Sava F, Carlsten C. Respiratory health effects of ambient air pollution: an update. Clin Chest Med 2012;33(4):759–69. - PubMed
    1. Beelen R, Stafoggia M, Raaschou-Nielsen O, Andersen ZJ, Xun WW, Katsouyanni K, et al. Long-term exposure to air pollution and cardiovascular mortality: an analysis of 22 European cohorts. Epidemiology 2014;25(3):368–78. - PubMed
    1. Shah AS, Lee KK, McAllister DA, Hunter A, Nair H, Whiteley W, et al. Short term exposure to air pollution and stroke: systematic review and meta-analysis. Br Med J 2015;350:h1295. - PMC - PubMed
    1. Demetriou CA, Raaschou-Nielsen O, Loft S, Møller P, Vermeulen R, Palli D, et al. Biomarkers of ambient air pollution and lung cancer: a systematic review. Occup Environ Med 2012;69(9):619–27. - PubMed
    1. Zhu X, Liu Y, Chen Y, Yao C, Che Z, Cao J. Maternal exposure to fine particulate matter (PM2.5) and pregnancy outcomes: a meta-analysis. Environ Sci Pollut Res Int 2015;22(5):3383–96. - PubMed

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