Review

. 2018 Jul 15;101(4):860-874.

doi: 10.1016/j.ijrobp.2018.03.002. Epub 2018 Mar 14.

The Children's Oncology Group Radiation Oncology Discipline: 15 Years of Contributions to the Treatment of Childhood Cancer

John C Breneman¹, Sarah S Donaldson², Louis Constine³, Thomas Merchant⁴, Karen Marcus⁵, Arnold C Paulino⁶, David Followill⁷, Anita Mahajan⁸, Nadia Laack⁸, Natia Esiashvili⁹, Daphne Haas-Kogan⁵, Fran Laurie¹⁰, Arthur Olch¹¹, Kenneth Ulin¹², David Hodgson¹³, Torunn I Yock¹⁴, Stephanie Terezakis¹⁵, Matt Krasin⁴, Joseph Panoff¹⁶, Paul Chuba¹⁷, Chia-Ho Hua⁴, Clayton B Hess¹⁴, Peter J Houghton¹⁸, Suzanne Wolden¹⁹, Jeff Buchsbaum²⁰, Thomas J Fitzgerald¹⁰, John A Kalapurakal²¹

Affiliations

¹ Department of Radiation Oncology, University of Cincinnati, Cincinnati, Ohio. Electronic address: brenemjc@ucmail.uc.edu.
² Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California.
³ Departments of Radiation Oncology and Pediatrics, University of Rochester Medical Center, Rochester, New York.
⁴ Department of Radiation Oncology, St Jude Children's Research Hospital, Memphis, Tennessee.
⁵ Department of Radiation Oncology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.
⁶ Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
⁷ Imaging and Radiation Oncology Core (IROC) Houston Quality Assurance Center, The University of Texas MD Anderson Cancer Center, Houston, Texas.
⁸ Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota.
⁹ Radiation Oncology Department, Winship Cancer Institute, Emory University, Atlanta, Georgia.
¹⁰ Imaging and Radiation Oncology Core (IROC) Rhode Island, Lincoln, Rhode Island.
¹¹ Radiation Oncology Program, Keck School of Medicine, University of Southern California, Los Angeles, California; Children's Hospital Los Angeles, Los Angeles, California.
¹² Imaging and Radiation Oncology Core (IROC) Rhode Island, Lincoln, Rhode Island; University of Massachusetts, Boston, Massachusetts.
¹³ Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, Ontario, Canada; Pediatric Oncology Group of Ontario, Toronto, Ontario, Canada.
¹⁴ Department of Radiation Oncology, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts.
¹⁵ Department of Radiation Oncology, Johns Hopkins University, Baltimore, Maryland.
¹⁶ 21st Century Oncology, Key West, Florida.
¹⁷ Department of Radiation Oncology, St John Hospital and Medical Center, Detroit, Michigan.
¹⁸ Greehey Children's Cancer Research Institute, The University of Texas Health Science Center at San Antonio, San Antonio, Texas.
¹⁹ Department of Radiation Oncology, Memorial Sloan Kettering, New York, New York.
²⁰ National Cancer Institute, Bethesda, Maryland.
²¹ Department of Radiation Oncology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

PMID: 29976498
PMCID: PMC6548440
DOI: 10.1016/j.ijrobp.2018.03.002

Review

The Children's Oncology Group Radiation Oncology Discipline: 15 Years of Contributions to the Treatment of Childhood Cancer

John C Breneman et al. Int J Radiat Oncol Biol Phys. 2018.

. 2018 Jul 15;101(4):860-874.

doi: 10.1016/j.ijrobp.2018.03.002. Epub 2018 Mar 14.

Authors

Affiliations

¹ Department of Radiation Oncology, University of Cincinnati, Cincinnati, Ohio. Electronic address: brenemjc@ucmail.uc.edu.
² Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California.
³ Departments of Radiation Oncology and Pediatrics, University of Rochester Medical Center, Rochester, New York.
⁴ Department of Radiation Oncology, St Jude Children's Research Hospital, Memphis, Tennessee.
⁵ Department of Radiation Oncology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.
⁶ Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
⁷ Imaging and Radiation Oncology Core (IROC) Houston Quality Assurance Center, The University of Texas MD Anderson Cancer Center, Houston, Texas.
⁸ Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota.
⁹ Radiation Oncology Department, Winship Cancer Institute, Emory University, Atlanta, Georgia.
¹⁰ Imaging and Radiation Oncology Core (IROC) Rhode Island, Lincoln, Rhode Island.
¹¹ Radiation Oncology Program, Keck School of Medicine, University of Southern California, Los Angeles, California; Children's Hospital Los Angeles, Los Angeles, California.
¹² Imaging and Radiation Oncology Core (IROC) Rhode Island, Lincoln, Rhode Island; University of Massachusetts, Boston, Massachusetts.
¹³ Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, Ontario, Canada; Pediatric Oncology Group of Ontario, Toronto, Ontario, Canada.
¹⁴ Department of Radiation Oncology, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts.
¹⁵ Department of Radiation Oncology, Johns Hopkins University, Baltimore, Maryland.
¹⁶ 21st Century Oncology, Key West, Florida.
¹⁷ Department of Radiation Oncology, St John Hospital and Medical Center, Detroit, Michigan.
¹⁸ Greehey Children's Cancer Research Institute, The University of Texas Health Science Center at San Antonio, San Antonio, Texas.
¹⁹ Department of Radiation Oncology, Memorial Sloan Kettering, New York, New York.
²⁰ National Cancer Institute, Bethesda, Maryland.
²¹ Department of Radiation Oncology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

PMID: 29976498
PMCID: PMC6548440
DOI: 10.1016/j.ijrobp.2018.03.002

Abstract

Purpose: Our aim was to review the advances in radiation therapy for the management of pediatric cancers made by the Children's Oncology Group (COG) radiation oncology discipline since its inception in 2000.

Methods and materials: The various radiation oncology disease site leaders reviewed the contributions and advances in pediatric oncology made through the work of the COG. They have presented outcomes of relevant studies and summarized current treatment policies developed by consensus from experts in the field.

Results: The indications and techniques for pediatric radiation therapy have evolved considerably over the years for virtually all pediatric tumor types, resulting in improved cure rates together with the potential for decreased treatment-related morbidity and mortality.

Conclusions: The COG radiation oncology discipline has made significant contributions toward the treatment of childhood cancer. Our discipline is committed to continuing research to refine and modernize the use of radiation therapy in current and future protocols with the goal of further improving the cure rates and quality of life of children with cancer.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest Statement: The authors of this manuscript have various financial disclosures outside the submitted work. One author is involved with an NIH Grant (CA180803) that coincides with the current work under consideration.

Figures

**Figure 1:**
ARST0332 guidelines for treatment of non-rhabdomyosarcoma soft tissue sarcomas. Management of these tumors is determined by extent of disease, grade, size, and margin status.

**Figure 2:**
Radiotherapy protocol compliance for AHOD0031. A: Compliance after central rapid review and remediation. B: Compliance in the absence of rapid review.

**Figure 3:**
COG membership breakdown. Radiation oncology committee members comprise 15% of the COG membership.

See this image and copyright information in PMC

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References

1. Siegel RL, Miller KD, Jemal A. Cancer Statistics, 2017. CA Cancer J Clin 2017;67:7–30. - PubMed
1. Constine LS, Tarbell NJ, Halperin EC. Pediatric Radiation Oncology. Philadelphia: Wolters Kluwer; 2016.
1. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2015. CA Cancer J Clin 2015;65:5–29. - PubMed
1. Thomas PR, Deutsch M, Kepner JL, et al. Low-stage medulloblastoma: final analysis of trial comparing standard-dose with reduced-dose neuraxis irradiation. J Clin Oncol 2000;18:3004–11. - PubMed
1. Packer RJ, Gajjar A, Vezina G, et al. Phase III study of craniospinal radiation therapy followed by adjuvant chemotherapy for newly diagnosed average-risk medulloblastoma. J Clin Oncol 2006;24:4202–8. - PubMed

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The Children's Oncology Group Radiation Oncology Discipline: 15 Years of Contributions to the Treatment of Childhood Cancer

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The Children's Oncology Group Radiation Oncology Discipline: 15 Years of Contributions to the Treatment of Childhood Cancer

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