Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018 Jul 15;101(4):860-874.
doi: 10.1016/j.ijrobp.2018.03.002. Epub 2018 Mar 14.

The Children's Oncology Group Radiation Oncology Discipline: 15 Years of Contributions to the Treatment of Childhood Cancer

John C Breneman  1 , Sarah S Donaldson  2 , Louis Constine  3 , Thomas Merchant  4 , Karen Marcus  5 , Arnold C Paulino  6 , David Followill  7 , Anita Mahajan  8 , Nadia Laack  8 , Natia Esiashvili  9 , Daphne Haas-Kogan  5 , Fran Laurie  10 , Arthur Olch  11 , Kenneth Ulin  12 , David Hodgson  13 , Torunn I Yock  14 , Stephanie Terezakis  15 , Matt Krasin  4 , Joseph Panoff  16 , Paul Chuba  17 , Chia-Ho Hua  4 , Clayton B Hess  14 , Peter J Houghton  18 , Suzanne Wolden  19 , Jeff Buchsbaum  20 , Thomas J Fitzgerald  10 , John A Kalapurakal  21
Affiliations
Review

The Children's Oncology Group Radiation Oncology Discipline: 15 Years of Contributions to the Treatment of Childhood Cancer

John C Breneman et al. Int J Radiat Oncol Biol Phys. .

Abstract

Purpose: Our aim was to review the advances in radiation therapy for the management of pediatric cancers made by the Children's Oncology Group (COG) radiation oncology discipline since its inception in 2000.

Methods and materials: The various radiation oncology disease site leaders reviewed the contributions and advances in pediatric oncology made through the work of the COG. They have presented outcomes of relevant studies and summarized current treatment policies developed by consensus from experts in the field.

Results: The indications and techniques for pediatric radiation therapy have evolved considerably over the years for virtually all pediatric tumor types, resulting in improved cure rates together with the potential for decreased treatment-related morbidity and mortality.

Conclusions: The COG radiation oncology discipline has made significant contributions toward the treatment of childhood cancer. Our discipline is committed to continuing research to refine and modernize the use of radiation therapy in current and future protocols with the goal of further improving the cure rates and quality of life of children with cancer.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest Statement: The authors of this manuscript have various financial disclosures outside the submitted work. One author is involved with an NIH Grant (CA180803) that coincides with the current work under consideration.

Figures

Figure 1:
Figure 1:
ARST0332 guidelines for treatment of non-rhabdomyosarcoma soft tissue sarcomas. Management of these tumors is determined by extent of disease, grade, size, and margin status.
Figure 2:
Figure 2:
Radiotherapy protocol compliance for AHOD0031. A: Compliance after central rapid review and remediation. B: Compliance in the absence of rapid review.
Figure 3:
Figure 3:
COG membership breakdown. Radiation oncology committee members comprise 15% of the COG membership.
See this image and copyright information in PMC

References

    1. Siegel RL, Miller KD, Jemal A. Cancer Statistics, 2017. CA Cancer J Clin 2017;67:7–30. - PubMed
    1. Constine LS, Tarbell NJ, Halperin EC. Pediatric Radiation Oncology. Philadelphia: Wolters Kluwer; 2016.
    1. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2015. CA Cancer J Clin 2015;65:5–29. - PubMed
    1. Thomas PR, Deutsch M, Kepner JL, et al. Low-stage medulloblastoma: final analysis of trial comparing standard-dose with reduced-dose neuraxis irradiation. J Clin Oncol 2000;18:3004–11. - PubMed
    1. Packer RJ, Gajjar A, Vezina G, et al. Phase III study of craniospinal radiation therapy followed by adjuvant chemotherapy for newly diagnosed average-risk medulloblastoma. J Clin Oncol 2006;24:4202–8. - PubMed

LinkOut - more resources