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. 2018 Jul 5;15(7):1415.
doi: 10.3390/ijerph15071415.

Association of Infant Eczema with Childhood and Adult Asthma: Analysis of Data from the 1958 Birth Cohort Study

Ghada Abo-Zaid  1   2 , Richard A Sharpe  3   4 , Lora E Fleming  5 , Michael Depledge  6 , Nicholas J Osborne  7   8
Affiliations

Association of Infant Eczema with Childhood and Adult Asthma: Analysis of Data from the 1958 Birth Cohort Study

Ghada Abo-Zaid et al. Int J Environ Res Public Health. .

Abstract

The influence of early life exposures on later life disease has for some time provided clues to modifiable risk factors of disease. The “atopic march” is thought to play a role in the progression of allergic diseases and may offer an opportunity to lower asthma’s health and socioeconomic burden, although evidence remains controversial. We aimed to examine the relationship between early life eczema and asthma later in life. Using the National Child Development Study, we examined infant eczema and childhood and adult asthma. Data related to asthma or wheezing bronchitis were available for 13,503 (73%; 95% CI 72⁻74), 11,503 (61%; 95% CI 60⁻61), 12,524 (68%; 95% CI 67⁻69), 11,194 (60%; 95% CI 60⁻60), 9377 (51%; 95% CI 51⁻51), and 9760 (53%; 95% CI 52⁻53) subjects at ages 11, 16, 23, 33, 44, and 50 years, respectively. Logistic regression models were fitted to examine each wave separately before and after adjusting for a range of potential confounders. Generalised estimating equation (GEE) methods were undertaken to examine the associations after pooling all data from questionnaires. The prevalence of self-reported asthma in those that had previously reported infant eczema ranged from 1.0%; 95% CI 0.9⁻1.4 (age 44 years) to 2.2%; 95% CI 2.1⁻2.3 (age 33 years). Participants with infant eczema had a 2⁻3-fold increased risk of reporting asthma in childhood and adulthood; this was 1.6 times at age 44 years when using spirometry measures. Similar effect sizes were observed in the GEE models when considering all participants (OR 2.9; 95% CI 2.6⁻3.2). Childhood and adult asthma were consistently associated with infant eczema both by using the self-reported data and lung measures.

Keywords: asthma; atopic march; eczema; longitudinal cohort study.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Brief explanation for the definitions and covariates that have been considered in the text.
Figure 2
Figure 2
The prevalence of current asthma or wheezing/bronchitis in the 1958BC study from 11 to 50 years of age.
See this image and copyright information in PMC

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References

    1. Pearce N., Aït-Khaled N., Beasley R., Mallol J., Keil U., Mitchell E., Robertson C. Worldwide trends in the prevalence of asthma symptoms: Phase III of the International Study of Asthma and Allergies in Childhood (ISAAC) Thorax. 2007;62:758–766. doi: 10.1136/thx.2006.070169. - DOI - PMC - PubMed
    1. Dharmage S., Lowe A., Matheson M., Burgess J., Allen K., Abramson M. Atopic dermatitis and the atopic march revisited. Allergy. 2014;69:17–27. doi: 10.1111/all.12268. - DOI - PubMed
    1. Sharpe R., Thornton C., Tyrrell J., Nikolaou V., Osborne N. Variable risk of atopic disease due to indoor fungal exposure in NHANES 2005–2006. Clin. Exp. Allergy. 2015;45:1566–1578. doi: 10.1111/cea.12549. - DOI - PubMed
    1. Spergel J.M., Paller A.S. Atopic dermatitis and the atopic march. J. Allergy Clin. Immunol. 2003;112:S118–S127. doi: 10.1016/j.jaci.2003.09.033. - DOI - PubMed
    1. Fu T., Keiser E., Linos E., Rotatori R.M., Sainani K., Lingala B., Lane A.T., Schneider L., Tang J.Y. Eczema and Sensitization to Common Allergens in the United States: A Multiethnic, Population-Based Study. Pediat. Dermatol. 2014;31:21–26. doi: 10.1111/pde.12237. - DOI - PubMed

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