Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Jan-Feb;26(1):63-66.
doi: 10.1590/1413-785220182601149210.

EFFICACY OF TRANEXAMIC ACID IN REDUCING BLOOD LOSS IN TOTAL KNEE ARTHROPLASTY

David Sadigursky  1   2 , Larissa Martins Araujo  3 , Rogério Jamil Carneiro Fernandes  2
Affiliations

EFFICACY OF TRANEXAMIC ACID IN REDUCING BLOOD LOSS IN TOTAL KNEE ARTHROPLASTY

David Sadigursky et al. Acta Ortop Bras. 2018 Jan-Feb.

Abstract
in English, Portuguese

Objective: To evaluate the efficacy of tranexamic acid in reducing blood loss in total knee arthroplasty by examining the existing literature.

Method: This literature review investigated the use of tranexamic acid in knee arthroplasty. The search was performed in the Pubmed, Science Direct, Google Scholar, and Lilacs databases over a 20-year period using the keywords: "knee arthroplasty, tranexamic acid, and efficacy". Only randomized clinical trials published between 2000 and 2016 in English, Spanish, or Portuguese were accepted, and only trials which scored above 3 on the Jadad scale were selected.

Results: A total of 7 randomized clinical trials met the inclusion criteria, with a sample of 948 patients.

Conclusion: The use of tranexamic acid in total knee arthroplasty (unilateral or bilateral) reduces perioperative and postoperative blood loss more than other available antifibrinolytics. With this reduction in total blood loss and the need for blood transfusions without any increase in side effects, the use of tranexamic acid can be considered safe and effective in controlling bleeding after knee arthroplasties. Level of Evidence II; Systematic review.

Objetivo: Avaliar a eficácia do ácido tranexâmico na redução da perda sanguínea em artroplastia total de joelho com relação à literatura existente.

Método: O presente artigo é uma revisão da literatura a respeito da utilização do ácido tranexâmico nas artroplastias de joelho. A busca foi realizada nas bases de dados do Pubmed, Science Direct, Google Scholar e Lilacs com os descritores: “knee arthroplasty”, “tranexamic acid”, and “efficacy”, ao longo de 20 anos. Foram aceitos apenas ensaios clínicos randomizados, publicados entre o período de 2000 e 2016, nos idiomas inglês, espanhol e português. Somente os ensaios graduados acima de três pela escala de Jadad foram selecionados.

Resultados: No total, sete ensaios clínicos randomizados satisfizeram os critérios de inclusão, com uma amostra de 948 pacientes.

Conclusão: O uso do ácido tranexâmico na artroplastia total do joelho, tanto uni quanto bilateral, reduz a perda de sangue no peri e no pós-operatório em comparação com outros antifibrinolíticos usados. Com a redução da perda total de sangue e da necessidade de transfusões sanguíneas, sem qualquer aumento dos efeitos colaterais, a utilização do uso do ácido tranexâmico pode ser considerada segura e eficaz no controle do sangramento depois de artroplastias do joelho. Nível de Evidência II; Revisão sistemática.

Keywords: Arthroplasty, replacement, knee; Bleeding; Efficacy; Tranexamic acid.

PubMed Disclaimer

Conflict of interest statement

All authors declare no potential conflict of interest related to this article.

Figures

Figure 1
Figure 1. Flowchart of results.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Marra F, Rosso F, Bruzzone M, Bonasia DE, Dettoni F, Rossi R. Use of tranexamic acid in total knee arthroplasty. Joints. 2017;4(4):202–213. - PMC - PubMed
    1. Chen T-P, Chen Y-M, Jiao J-B, Wang Y-F, Qian L-G, Guo Z. Comparison of the effectiveness and safety of topical versus intravenous tranexamic acid in primary total knee arthroplasty a meta-analysis of randomized controlled trials. J Orthop Surg. 2017;12(1):11–11. - PMC - PubMed
    1. Wang Z, Shen X. The efficacy of combined intra-articular and intravenous tranexamic acid for blood loss in primary total knee arthroplasty A meta-analysis. Medicine (Baltimore) 2017;96(42):e8123. - PMC - PubMed
    1. Zhang H, Chen J, Chen F, Que W. The effect of tranexamic acid on blood loss and use of blood products in total knee arthroplasty a meta-analysis. Knee Surg Sports Traumatol Arthrosc Off J ESSKA. 2012;20(9):1742–1752. - PubMed
    1. Kim TK, Chang CB, Koh IJ. Practical issues for the use of tranexamic acid in total knee arthroplasty a systematic review. Knee Surg Sports Traumatol Arthrosc Off J ESSKA. 2014;22(8):1849–1858. - PubMed

LinkOut - more resources