Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1985 Sep 25;13(18):6651-61.
doi: 10.1093/nar/13.18.6651.

Sequence of the D beta 2-J beta 2 region of the human T-cell receptor beta-chain locus

A Tunnacliffe, T H Rabbitts
Free PMC article
Comparative Study

Sequence of the D beta 2-J beta 2 region of the human T-cell receptor beta-chain locus

A Tunnacliffe et al. Nucleic Acids Res. .
Free PMC article

Abstract

We have sequenced the region encompassing a D beta 2 segment and the J beta 2 segments of the human T-cell antigen receptor beta-chain genes. The D beta 2 element lies about 650 base pairs upstream of a cluster of seven potentially functional J beta 2 sequences and one J beta 2 pseudogene. Examination of human beta-chain cDNA sequences which involve rearranged D beta 2 and J beta 2 elements demonstrates that N-region, as well as junctional, diversity can occur during D-J joining. Further, we present evidence for possible somatic mutation in active J beta 2 segments.

PubMed Disclaimer

References

    1. Proc Natl Acad Sci U S A. 1977 Dec;74(12):5463-7 - PubMed
    1. Cell. 1984 Jul;37(3):1101-10 - PubMed
    1. Nature. 1981 Apr 16;290(5807):562-5 - PubMed
    1. Nature. 1981 Dec 17;294(5842):631-5 - PubMed
    1. J Exp Med. 1982 Jan 1;155(1):201-18 - PubMed

Publication types

Associated data