Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Mar;18(1):66-71.
doi: 10.4314/ahs.v18i1.10.

Predictors of esophageal candidiasis among patients attending endoscopy unit in a tertiary hospital, Tanzania: a retrospective cross-sectional study

Martha F Mushi  1 , Nathaniel Ngeta  2 , Mariam M Mirambo  1 , Stephen E Mshana  1
Affiliations

Predictors of esophageal candidiasis among patients attending endoscopy unit in a tertiary hospital, Tanzania: a retrospective cross-sectional study

Martha F Mushi et al. Afr Health Sci. 2018 Mar.

Abstract

Background: Esophageal candidiasis is a common disease among patients with impaired cell mediated immunity. In the current study, we report esophageal candidiasis among patients with various co-morbidities attending the endoscopic unit at the Bugando Medical Centre.

Methods: This retrospective study was conducted from June to September 2015. All data of the patients who attended the endoscopic unit between 2009 and 2014 were retrieved and analyzed.

Results: A total of 622 patients who underwent oesophagogastroduodenoscopy were analyzed. A slight majority 334/622(53.7%) of patients were female. Out of 622 patients; 35(5.6%) had esophageal candidiasis. Decrease in age (OR 1.1, 95%CI; 1.0-1.1), female sex (OR 3.8, 95%CI; 1.1-13.1), drinking alcohol (OR 17.1, 95%CI; 4.9-58.9), smoking (OR 8.3, 95%CI; 1.7-41.0), antibiotic use (OR 5.7, 95%CI; 2.0-16.4), positive HIV status (OR 10.3, 95%CI; 4.6-6.0) and presence of peptic ulcer disease (OR 13.2, 95%CI; 3.5-49.0) independently predicted esophageal candidiasis.

Conclusion: Patients with a history of drinking alcohol, smoking, use of antibiotics and those with chronic diseases such as peptic ulcers were at high risk of developing esophageal candidiasis. Further studies are needed to identify Candida spp. and their anti-fungal susceptibility for proper management of esophageal candidiasis in HIV and non-HIV individuals.

Keywords: Esophagogastroduodenoscopy; esophageal candidiasis.

PubMed Disclaimer

Comment in

References

    1. Feigal DW, Katz MH, Greenspan D, Westenhouse J, Winkelstein W, Jr, Lang W, Samuel M, Buchbinder SP, Hessol NA, Lifson AR. The prevalence of oral lesions in HIV-infected homosexual and bisexual men: three San Francisco epidemiological cohorts. Aids. 1991;5(5):519–526. - PubMed
    1. Laine L, Bonacini M. Esophageal disease in human immunodeficiency virus infection. Archives of Internal Medicine. 1994;154(14):1577–1582. - PubMed
    1. LP S. Oral mycoses in HIV infection. Oral Surg Oral Med Oral Pathol. 1992;73(2):171–180. - PubMed
    1. Thapa B, Kumar L. Candida esophagitis after antibiotic use. Indian Journal of Pediatrics. 1989;56(2):296–299. - PubMed
    1. Kochhar R, Talwar P, Singh S, Mehta S. Invasive candidiasis following cimetidine therapy. The American Journal of Gastroenterology. 1988;83(1):102–103. - PubMed

LinkOut - more resources