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Review
. 2018 Jun 22:10:1758835918780312.
doi: 10.1177/1758835918780312. eCollection 2018.

Therapy of breast cancer brain metastases: challenges, emerging treatments and perspectives

Nuria Kotecki  1 , Florence Lefranc  2 , Daniel Devriendt  3 , Ahmad Awada  4
Affiliations
Review

Therapy of breast cancer brain metastases: challenges, emerging treatments and perspectives

Nuria Kotecki et al. Ther Adv Med Oncol. .

Abstract

Brain metastases are the most common central nervous system tumors in adults, and incidence of brain metastases is increasing due to both improved diagnostic techniques (e.g. magnetic resonance imaging) and increased cancer patient survival through advanced systemic treatments. Outcomes of patients remain disappointing and treatment options are limited, usually involving multimodality approaches. Brain metastases represent an unmet medical need in solid tumor care, especially in breast cancer, where brain metastases are frequent and result in impaired quality of life and death. Challenges in the management of brain metastases have been highlighted in this review. Innovative research and treatment strategies, including prevention approaches and emerging systemic treatment options for brain metastases of breast cancer, are further discussed.

Keywords: brain metastases; breast cancer; challenges; innovation; therapy.

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Conflict of interest statement

Conflict of interest statement: The authors declare that there is no conflict of interest.

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