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. 2018 May 27:2018:2410451.
doi: 10.1155/2018/2410451. eCollection 2018.

A Preliminary Study of microRNA-208b after Acute Myocardial Infarction: Impact on 6-Month Survival

Mostafa Alavi-Moghaddam  1   2 , Mohammad Chehrazi  3 , Shamila D Alipoor  4 , Maryam Mohammadi  1 , Alireza Baratloo  5 , Mohammad Parsa Mahjoub  6 , Mehrnaz Movasaghi  7 , Johan Garssen  8   9 , Ian M Adcock  10   11 , Esmaeil Mortaz  7   12
Affiliations

A Preliminary Study of microRNA-208b after Acute Myocardial Infarction: Impact on 6-Month Survival

Mostafa Alavi-Moghaddam et al. Dis Markers. .

Abstract

Introduction: miRNAs contribute to a variety of essential biological processes including development, proliferation, differentiation, and apoptosis. Circulating microRNAs are very stable and have shown potential as biomarkers of cardiovascular disease. microRNA-208b expression was increased in the blood of patients with acute myocardial infarction (AMI) and has been proposed as a biomarker for early diagnosis. In this pilot study, we investigate the potential of circulating miR-208b as a prognostic biomarker of 6-month survival in AMI patients.

Methods: Plasma samples from 21 patients and 8 age- and gender-matched healthy adults were collected, and circulating levels of miR-208b were detected using quantitative real-time PCR.

Results: miR-208b levels were higher in healthy control subjects (9.6-fold; P ≤ 0.05). Within the AMI patients, the levels of miR-208b were significantly lower in the survivor versus nonsurvivor group (fold change = 6.51 and 14.1, resp.; P ≤ 0.05). The Kaplan-Meier curve revealed that the 6-month survival time was significantly higher among AMI patients with a relative expression of miR-208b lower than 12.38. The hazard ratio (HR) for the relative expression of miR-208b (<12.38 was the reference) was 5.08 (95% CI: 1.13-22.82; P = 0.03).

Conclusion: Our results showed that elevated miR-208b expression was associated with reduced long-term survival in AMI patients. These pilot data indicate the need for a large follow-up study to confirm whether miR-208b can be used as a predictor of 6-month survival time after AMI.

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Figures

Figure 1
Figure 1
(a) Relative expression of circulating miR-208b in AMI patients in the survivor and nonsurvivor groups (P = 0.03). The expression of miR-208b was 9.6-fold higher in the AMI group compared with the healthy control subjects. (b) The relative expression of miR-208b was increased in both survivor and nonsurvivor groups in comparison to healthy subjects (fold change = 6.51 and 14.1, resp.). Plasma samples were collected upon admission no more than 24 h after AMI onset (in all cases, P value ≤ 0.05).
Figure 2
Figure 2
Kaplan-Meier curve displaying the survival in relation to high or low miR-208b relative expression.
See this image and copyright information in PMC

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