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. 1985 Oct 25;13(20):7257-68.
doi: 10.1093/nar/13.20.7257.

The nucleotide sequence of the yeast MEL1 gene

P L Liljeström
Free PMC article

The nucleotide sequence of the yeast MEL1 gene

P L Liljeström. Nucleic Acids Res. .
Free PMC article

Abstract

The complete nucleotide sequence of the MEL1 gene of the yeast, Saccharomyces cerevisiae, encoding alpha-galactosidase was determined. The nucleotide sequence contains an open reading frame of 1413 bp encoding a protein of 471 amino acids. Comparison with the known N-terminal amino acid sequence of the mature secreted protein indicated that alpha-galactosidase is synthesized as a precursor with an N-terminal signal sequence of 18 amino acids. The general features of this signal peptide resemble those of other yeast signal peptides. Molecular weight of the mature alpha-galactosidase polypeptide deduced from the nucleotide sequence is 50.049 kd. The 5' regulatory region has sequences in common with other yeast genes regulated by the GAL4-protein.

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