Harnessing Oxidative Stress as an Innovative Target for Cancer Therapy

Lynne Postovit¹, Christian Widmann², Peng Huang³, Spencer B Gibson^{4

5}

Affiliations

¹ Department of Oncology, University of Alberta, Edmonton, AB, Canada.
² Department of Physiology, University of Lausanne, Lausanne, Switzerland.
³ Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
⁴ Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, MB, Canada.
⁵ Research Institute in Oncology and Hematology, CancerCare Manitoba, Winnipeg, MB, Canada.

PMID: 29977457
PMCID: PMC5994291
DOI: 10.1155/2018/6135739

Editorial

Harnessing Oxidative Stress as an Innovative Target for Cancer Therapy

Lynne Postovit et al. Oxid Med Cell Longev. 2018.

. 2018 May 24:2018:6135739.

doi: 10.1155/2018/6135739. eCollection 2018.

Authors

Lynne Postovit¹, Christian Widmann², Peng Huang³, Spencer B Gibson^{4

5}

Affiliations

¹ Department of Oncology, University of Alberta, Edmonton, AB, Canada.
² Department of Physiology, University of Lausanne, Lausanne, Switzerland.
³ Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
⁴ Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, MB, Canada.
⁵ Research Institute in Oncology and Hematology, CancerCare Manitoba, Winnipeg, MB, Canada.

PMID: 29977457
PMCID: PMC5994291
DOI: 10.1155/2018/6135739

No abstract available

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References

1. Hanahan D., Weinberg R. A. Hallmarks of cancer: the next generation. Cell. 2011;144(5):646–674. doi: 10.1016/j.cell.2011.02.013. - DOI - PubMed
1. Azad M. B., Chen Y., Gibson S. B. Regulation of autophagy by reactive oxygen species (ROS): implications for cancer progression and treatment. Antioxidants & Redox Signaling. 2009;11(4):777–790. doi: 10.1089/ars.2008.2270. - DOI - PubMed
1. Moloney J. N., Cotter T. G. ROS signalling in the biology of cancer. Seminars in Cell & Developmental Biology. 2017;(16):30383–30384. doi: 10.1016/j.semcdb.2017.05.023. - DOI - PubMed
1. Xie H., Simon M. C. Oxygen availability and metabolic reprogramming in cancer. Journal of Biological Chemistry. 2017;292(41):16825–16832. doi: 10.1074/jbc.R117.799973. - DOI - PMC - PubMed
1. Fung M. K. L., Chan G. C.-F. Drug-induced amino acid deprivation as strategy for cancer therapy. Journal of Hematology & Oncology. 2017;10(1):p. 144. doi: 10.1186/s13045-017-0509-9. - DOI - PMC - PubMed

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Harnessing Oxidative Stress as an Innovative Target for Cancer Therapy

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Harnessing Oxidative Stress as an Innovative Target for Cancer Therapy

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