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Review
. 2018 Jun 1:16:190-195.
doi: 10.1016/j.csbj.2018.05.002. eCollection 2018.

ctDNA and CTCs in Liquid Biopsy - Current Status and Where We Need to Progress

Martin H D Neumann  1 , Sebastian Bender  2 , Thomas Krahn  1 , Thomas Schlange  1
Affiliations
Review

ctDNA and CTCs in Liquid Biopsy - Current Status and Where We Need to Progress

Martin H D Neumann et al. Comput Struct Biotechnol J. .

Abstract

We discuss the current status of liquid biopsy and its advantages and challenges with a focus on pre-analytical sample handling, technologies and workflows. The potential of circulating tumor cells and circulating tumor DNA is pointed out and an overview of corresponding technologies is given.

Keywords: Circulating tumor DNA; Circulating tumor cells; Liquid biopsy; Pre-analytical handling; Technology overview.

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Figures

Fig. 1
Fig. 1
Commercialized methods for analysis of genetic alterations, categorized by the “size” of the genetic alteration. Not all technologies shown here are also currently applied for liquid biopsy or do not have the potential to be applied for it.
See this image and copyright information in PMC

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